Open Access Research article

A genetic predisposition score for muscular endophenotypes predicts the increase in aerobic power after training: the CAREGENE study

Tom Thomaes1*, Martine Thomis2, Steven Onkelinx1, Robert Fagard3, Gert Matthijs4, Roselien Buys1, Dirk Schepers1, Véronique Cornelissen1 and Luc Vanhees1

Author Affiliations

1 Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Heverlee, Belgium

2 Research Centre for Exercise and Health, Department of Biomedical Kinesiology, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Heverlee, Belgium

3 Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium

4 Department of Human Genetics, Centre for Human Genetics of the University Hospitals, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium

For all author emails, please log on.

BMC Genetics 2011, 12:84  doi:10.1186/1471-2156-12-84

Published: 3 October 2011

Additional files

Additional file 1:

The selected increasing alleles for calculation of the GPS score of the increasing allele analysis. For the 'increasing allele' analysis a selection of 7 polymorphisms was made based on recent literature. The increasing allele is indicated here for each selected polymorphism.

Format: DOC Size: 20KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Genotype-phenotype association analysis for muscular subsystem gene polymorphisms and baseline aerobic power and changes after training in the CAREGENE study (without correction for baseline peakVO2). As we might be overcorrecting the increase in peakVO2 by using baseline peak VO2 values as a covariate, the results of Table 3 are shown here without correction for baseline peakVO2.

Format: DOC Size: 35KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data