Table 1

Demographic, parasitological, and clinical characteristics of the study participants upon enrolment

Characteristic

Non-SMA

SMA

P


Participants, n

304

240

N/A

Gender, female, n (%)

140 (46.1)

122 (50.8)

0.268a

Age, months

11 (10)

8 (7)

<0.001b

Axillary temperature, °C

37.5 (1.7)

37.4 (1.5)

<0.001b

Haemoglobin, g/dL

7.8 (2.7)

4.9 (1.4)

<0.001b

White blood cells, (×109/L)

10.9 (5.4)

13.1 (7.9)

<0.001b

Parasite density,/μL

19,932 (40,097)

17,262 (41,739)

0.446b

Geomean parasitaemia,/μL

14,486

12,598

0.678c

High-density parasitaemia, n (%)

201 (66.1)

142 (59.2)

0.057a

Sickle-cell trait, n (%)

49 (16.1)

6 (2.5)

0.054a


Data are median values (interquartile range; IQR) unless otherwise noted. Children with P. falciparum malaria (n = 544) were categorized according to SMA status based on age- and geographically-appropriate Hb concentrations [i.e., Hb<6.0 g/dL, with any density parasitaemia) [4]] and non-SMA (Hb≥6.0 g/dL, with any density parasitaemia). High density parasitaemia (≥10,000 parasites/μL). aStatistical significance determined by Chi-square analysis. bStatistical significance determined by Mann-Whitney U test. cStatistical significance determined by independent groups t-test.

Ong'echa et al. BMC Genetics 2011 12:69   doi:10.1186/1471-2156-12-69

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