Table 4

Beagle association chi-square results

Gene Name

Designator

H

Chi Square

P-Value

Results


*ARX

First Set

0.508

0.643

Not Significant

*CACNA1A

First Set

0.636

0.813

Not Significant

CACNA1B

First Set

0.836

0.765

Not Significant

CACNA1D

First Set

0.123

(---)

Low Heterozygosity

CACNA1E

First Set

0.697

0.254

Not Significant

CACNA1F

First Set

0.671

0.578

Not Significant

CACNA1G

First Set

0.640

0.092

Not Significant

*CACNA1H

Second Set

0.344

0.873

Not Significant

CACNA1I

First Set

0.570

0.365

Not Significant

#CACNA2D2

First Set

0.438

0.917

Not Significant

CACNB1

First Set

0.318

0.661

Not Significant

CACNB2

First Set

0.612

0.577

Not Significant

CACNB3

First Set

0.577

0.148

Not Significant

*CACNB4

First Set

0.864

0.753

Not Significant

#CACNG2

First Set

0.720

0.502

Not Significant

CACNG3

First Set

0.135

(---)

Low Heterozygosity

CACNG4

First Set

0.633

0.816

Not Significant

CACNG6

First Set

0.505

0.413

Not Significant

CHRNA1

First Set

0.686

0.050

Not Significant

CHRNA1

Second Set

0.506

0.600

Not Significant

CHRNA1

Third Set

0.661

0.072

Not Significant

CHRNA1

Fourth Set

0.790

0.056

Not Significant

*CHRNA2

First Set

0.664

0.590

Not Significant

*CHRNA4 and KCNQ2

See KCNQ2

CHRNA7

First Set

0.741

0.513

Not Significant

CHRNA9

First Set

0.665

0.694

Not Significant

CHRNB1

First Set

0.491

0.555

Not Significant

*CHRNB2

First Set

0.583

0.885

Not Significant

*CLCN2

First Set

0.762

0.577

Not Significant

DNM1

First Set

0.278

(---)

Low Heterozygosity

DNM1

Second Set

0.386

0.693

Not Significant

DNM1

Third Set

0.588

0.314

Not Significant

DNM1

Fourth Set

0.565

0.953

Not Significant

DNM1

Fifth Set

0.563

0.430

Not Significant

*GABRA1

First Set

0.523

0.345

Not Significant

GABRA2

First Set

0.502

0.265

Not Significant

GABRA6

First Set

0.575

0.266

Not Significant

*GABRD

First Set

0.684

0.554

Not Significant

*GABRG2

First Set

0.748

0.292

Not Significant

*GABRG2

Second Set

0.447

0.849

Not Significant

*KCNA1

First Set

0.758

0.356

Not Significant

KCND2

First Set

0.530

0.919

Not Significant

KCND2

Second Set

0.706

0.698

Not Significant

KCND2

Third Set

0.728

0.455

Not Significant

*KCNQ2 and CHRNA4

Second Set

0.805

0.627

Not Significant

*KCNQ3

First Set

0.655

0.077

Not Significant

KCNQ5

First Set

0.106

(---)

Low Heterozygosity

*LGI1

First Set

0.234

(---)

Low Heterozygosity

*LGI1

Second Set

0.708

0.070

Not Significant

*ME2

First Set

0.585

0.282

Not Significant

*NHLRC1

First Set

0.605

0.739

Not Significant

*SCN1A

First Set

0.118

(---)

Low Heterozygosity

*SCN1A

Third Set

0.328

0.551

Not Significant

*SCN1B

First Set

0.679

0.425

Not Significant

*SCN1B

Second Set

0.649

0.885

Not Significant

*SCN2A

First Set

0.680

0.763

Not Significant

SCN3B

First Set

0.750

0.127

Not Significant

SCN8A

First Set

0.730

0.110

Not Significant

SCN11A

First Set

0.689

0.572

Not Significant


Bolded genes marked with a * indicate those associated with human IE, and bolded genes marked with a # indicate those associated with mouse models of epilepsy. The breed cohort was assembled and statistics were performed as described in Materials and Methods. "Designator" indicates each set of primers, first, second, etc., designed for that gene and used in this breed (See Additional files 1 and 2). H = heterozygosity of the marker.

Ekenstedt et al. BMC Genetics 2011 12:38   doi:10.1186/1471-2156-12-38

Open Data