Table 2

English Springer Spaniel association chi-square results

Gene Name

Designator

H

Chi Square

P-Value

Results


*ARX

First Set

0.485

0.843

Not Significant

*CACNA1A

First Set

0.312

0.308

Not Significant

CACNA1B

First Set

0.062

(---)

Low Heterozygosity

CACNA1D

First Set

0.000

(---)

Monomorphic

CACNA1E

First Set

0.684

0.314

Not Significant

CACNA1F

First Set

0.454

0.097

Not Significant

CACNA1G

First Set

0.467

0.916

Not Significant

*CACNA1H

First Set

0.734

0.644

Not Significant

CACNA1I

First Set

0.546

0.135

Not Significant

#CACNA2D2

First Set

0.369

0.898

Not Significant

CACNB1

First Set

0.734

0.744

Not Significant

CACNB2

First Set

0.619

0.305

Not Significant

CACNB3

First Set

0.362

0.113

Not Significant

*CACNB4

First Set

0.830

0.989

Not Significant

#CACNG2

First Set

0.413

0.963

Not Significant

CACNG3

First Set

0.653

0.130

Not Significant

CACNG4

First Set

0.635

0.220

Not Significant

CACNG6

First Set

0.561

0.267

Not Significant

CHRNA1

First Set

0.538

0.249

Not Significant

*CHRNA2

First Set

0.233

(---)

Low Heterozygosity

*CHRNA4 and KCNQ2

See KCNQ2

CHRNA5

First Set

0.436

0.788

Not Significant

CHRNA7

First Set

0.692

0.622

Not Significant

CHRNA9

First Set

0.259

(---)

Low Heterozygosity

CHRNB1

First Set

0.207

(---)

Low Heterozygosity

*CHRNB2

First Set

0.173

(---)

Low Heterozygosity

*CHRNB2

Second Set

0.198

(---)

Low Heterozygosity

*CHRNB2

Third Set

0.321

0.982

Not Significant

*CLCN2

First Set

0.492

0.719

Not Significant

DNM1

First Set

0.227

(---)

Low Heterozygosity

DNM1

Second Set

0.528

0.886

Not Significant

DNM1

Third Set

0.700

0.598

Not Significant

DNM1

Fourth Set

0.714

0.875

Not Significant

DNM1

Fifth Set

0.618

0.853

Not Significant

*GABRA1

First Set

0.416

0.074

Inconclusive

*GABRA1

Second Set

0.490

0.033

Inconclusive

*GABRA1

Third Set

0.369

0.890

Not Significant

*GABRD

First Set

0.257

(---)

Low Heterozygosity

*GABRD

Second Set

0.223

(---)

Low Heterozygosity

*GABRD

Third Set

0.295

(---)

Low Heterozygosity

*GABRG2

First Set

0.663

0.443

Not Significant

*KCNA1

First Set

0.587

0.965

Not Significant

KCND2

First Set

0.233

(---)

Low Heterozygosity

*KCNQ2 and CHRNA4

Second Set

0.738

0.710

Not Significant

*KCNQ3

First Set

0.541

0.474

Not Significant

KCNQ5

First Set

0.206

(---)

Low Heterozygosity

*LGI1

First Set

0.641

0.834

Not Significant

*ME2

First Set

0.492

0.619

Not Significant

*NHLRC1

Second Set

0.684

0.784

Not Significant

*SCN1A

First Set

0.199

(---)

Low Heterozygosity

*SCN1A

Second Set

0.082

(---)

Low Heterozygosity

*SCN1A

Third Set

0.211

(---)

Low Heterozygosity

*SCN1A

Fourth Set

0.337

0.968

Not Significant

*SCN1B

First Set

0.676

0.216

Not Significant

*SCN2A

First Set

0.766

0.670

Not Significant

SCN3A

First Set

0.000

(---)

Monomorphic

SCN3A

Second Set

0.069

(---)

Low Heterozygosity

SCN3B

First Set

0.563

0.834

Not Significant

SCN8A

First Set

0.070

(---)

Low Heterozygosity

SCN8A

Second Set

0.000

(--)

Monomorphic

SCN11A

First Set

0.637

0.396

Not Significant


Bolded genes marked with a * indicate those associated with human IE, and bolded genes marked with a # indicate those associated with mouse models of epilepsy. The breed cohort was assembled and statistics were performed as described in Materials and Methods. "Designator" indicates each set of primers, first, second, etc., designed for that gene and used in this breed (See Additional files 1 and 2). H = heterozygosity of the marker.

Ekenstedt et al. BMC Genetics 2011 12:38   doi:10.1186/1471-2156-12-38

Open Data