Table 1

Vizsla two-point linkage analysis results

Gene Name

Designator

H

LOD at 0 cM

(10 Fam)

Results


*ARX

First Set

0.555

(-)16.99

Excluded

*CACNA1A

First Set

0.163

(---)

Low Heterozygosity

*CACNA1A

Second Set

0.180

(---)

Low Heterozygosity

*CACNA1A

Third Set

0.142

(---)

Low Heterozygosity

*CACNA1A

Fourth Set

0.659

(-)8.06

Excluded

CACNA1B

First Set

0.757

(-)7.78

Excluded

CACNA1D

First Set

0.725

(-)16.18

Excluded

CACNA1E

First Set

0.783

(-)11.03

Excluded

CACNA1F

First Set

0.655

(-)23.95

Excluded

CACNA1G

First Set

0.584

(-)12.33

Excluded

*CACNA1H

First Set

0.000

(---)

Monomorphic

*CACNA1H

Second Set

0.423

(-)7.59

Excluded

CACNA1I

First Set

0.275

(---)

Low Heterozygosity

#CACNA2D2

First Set

0.495

(-)1.34

Neither Linked Nor Unlinked

#CACNA2D2

Second Set

0.665

(-)6.88

Excluded

CACNB1

First Set

0.548

0.82

Neither Linked Nor Unlinked

CACNB2

First Set

0.670

(-)1.39

Neither Linked Nor Unlinked

CACNB3

First Set

0.203

(---)

Low Heterozygosity

*CACNB4

First Set

0.781

(-)6.08

Excluded

#CACNG2

First Set

0.739

(-)21.61

Excluded

CACNG3

First Set

0.628

(-)10.69

Excluded

CACNG4

First Set

0.615

(-)8.70

Excluded

CACNG6

First Set

0.530

(-)8.35

Excluded

CHRNA1

First Set

0.291

(---)

Low Heterozygosity

CHRNA3

First Set

0.629

(-)3.58

Excluded

*CHRNA4 and KCNQ2

See KCNQ2

CHRNA7

First Set

0.695

(-)9.65

Excluded

CHRNA9

First Set

0.420

(-)4.54

Excluded

CHRNA10

First Set

0.795

(-)6.43

Excluded

CHRNB1

First Set

0.587

(-)4.62

Excluded

*CHRNB2

First Set

0.725

(-)18.39

Excluded

CHRND

First Set

0.655

(-)5.05

Excluded

*CLCN2

First Set

0.665

(-)4.75

Excluded

DNM1

First Set

0.495

(-)3.63

Excluded

DNM1

Fourth Set

0.355

(-)3.77

Excluded

DNM1

Fifth Set

0.677

(-)3.93

Excluded

*GABRA1

First Set

0.605

(-)6.12

Excluded

GABRA2

First Set

0.575

(-)20.25

Excluded

GABRA6

First Set

0.646

(-)10.69

Excluded

*GABRD

First Set

0.745

(-)3.73

Excluded

*GABRG2

First Set

0.773

(-)22.33

Excluded

*GABRG2

Second Set

0.455

(-)4.39

Excluded

*KCNA1

First Set

0.716

(-)6.71

Excluded

KCNQ1

First Set

0.495

(-)3.10

Excluded

*KCNQ2 and CHRNA4

Second Set

0.578

(-)1.50

Neither Linked Nor Unlinked

*KCNQ2 and CHRNA4

Third Set

0.526

(-)0.49

Neither Linked Nor Unlinked

*KCNQ2 and CHRNA4

Fourth Set

0.676

(-)11.37

Excluded

*KCNQ3

First Set

0.711

(-)2.01

Excluded

KCNQ5

First Set

0.535

(-)5.29

Excluded

*LGI1

First Set

0.725

(-)9.89

Excluded

*ME2

First Set

0.625

(-)7.89

Excluded

*NHLRC1

Second Set

0.509

(-)8.49

Excluded

*SCN1A

First Set

0.600

(-)7.83

Excluded

*SCN1B

First Set

0.820

(-)8.52

Excluded

*SCN2A

First Set

0.833

(-)13.95

Excluded

SCN3A

First Set

0.000

(---)

Monomorphic

SCN3A

Second Set

0.545

(-)5.82

Excluded

SCN3B

First Set

0.751

(-)21.76

Excluded

SCN8A

First Set

0.805

(-)18.57

Excluded

SCN11A

First Set

0.255

(---)

Low Heterozygosity


Bolded genes marked with a * indicate those associated with human IE, and bolded genes marked with a # indicate those associated with mouse models of epilepsy. The breed cohort was assembled and statistics were performed as described in Materials and Methods. "Designator" indicates each set of primers, first, second, etc., designed for that gene and used in this breed (See Additional files 1 and 2). H = heterozygosity of the marker.

Ekenstedt et al. BMC Genetics 2011 12:38   doi:10.1186/1471-2156-12-38

Open Data