Table 3

Genotype associations

MCP1

GT

cases n (frequency)

controls n (frequency)

OR

CI

Pnom

Pcorr

ORtrend

CI

Pnom

Pcorr


-97569

CC

278 (0.14)

328 (0.14)

1

1.00

[0.92-1.10]

0.99

CG

941 (0.47)

1089 (0.47)

1.02

[0.85-1.23]

0.81

GG

765 (0.39)

900 (0.39)

1.01

[0.84-1.22]

0.92

-38600

CC

629 (0.32)

666 (0.29)

1

0.91

[0.83-0.99]

0.03

CT

970 (0.49)

1131 (0.50)

0.91

[0.79-1.05]

0.20

TT

380 (0.19)

488 (0.21)

0.83

[0.70-0.99]

0.03

-2581*

AA

1355 (0.69)

1472 (0.64)

1

0.81

[0.73-0.91]

0.0003

0.0018

AG

546 (0.28)

748 (0.32)

0.79

[0.69-0.90]

0.001

0.006

GG

63 (0.03)

92 (0.04)

0.73

[0.53-1.02]

0.064

-1727

TT

1708 (0.94)

1994 (0.93)

1

0.88

[0.69-1.13]

0.32

AT

109 (0.06)

145 (0.07)

0.87

[0.67-1.12]

0.27

AA

2 (<0.01)

2 (<0.01)

1.34

[0.19-9.58]

0.77

-362*

GG

672 (0.34)

654 (0.28)

1

0.83

[0.76-0.91]

0.000026

0.00021

CG

922 (0.47)

1133 (0.49)

0.80

[0.69-0.92]

0.001

0.008

GG

374 (0.19)

514 (0.22)

0.70

[0.59-0.83]

0.00005

0.0004

Int1:96

CC

145 (0.09)

152 (0.07)

1

0.87

[0.78-0.96]

0.006

CG

677 (0.40)

788 (0.37)

0.90

[0.70-1.16]

0.4

GG

862 (0.51)

1170 (0.55)

0.77

[0.60-0.98]

0.037

Int1:554

WW

743 (0.37)

734 (0.31)

1

0.84

[0.77-0.92]

0.00014

0.00098

-567

DW

946 (0.47)

1178 (0.50)

0.80

[0.70-0.91]

0.0009

0.0063

DD

320 (0.16)

425 (0.18)

0.73

[0.60-0.98]

0.0006

0.0042

+1542

CC

1358 (0.68)

1494 (0.64)

1

0.86

[0.77-0.96]

0.009

CT

575 (0.29)

757 (0.32)

0.84

[0.73-0.95]

0.007

TT

68 (0.03)

88 (0.04)

0.84

[0.60-1.16]

0.29

+2413

GG

813 (0.86)

1232 (0.86)

1

1.02

[0.92-1.29]

0.819

GT

124 (0.13)

188 (0.13)

0.99

[0.78-1.28]

0.99

TT

5 (<0.01)

5 (<0.01)

1.54

[0.44-5-47]

0.5

+2580

AA

26 (0.01)

21 (<0.01)

1

0.97

[0.84-1.12]

0.711

AT

345 (0.17)

412 (0.18)

0.69

[0.38-1.25]

0.22

TT

1623 (0.81)

1886 (0.81

0.70

[0.39-1.25]

0.23


GT, genotype; Int1, intron 1; D, deletion; W, wildtype; OR, odds ratio; CI, 95% confidence interval. P values are adjusted for age, gender and ethnicity. Pnom, nominal P value; Pcorr, P value after Bonferroni-Holm correction. ORtrend, estimates of an additive genetic model; *Variants -2581 and -362 were originally genotyped and described in [14].

Intemann et al. BMC Genetics 2011 12:34   doi:10.1186/1471-2156-12-34

Open Data