Table 1

Parameters for Simulation under Alternative Hypothesis

Disease Locus 1

Marker 1

Disease Locus 2

Marker 2

(D1)

(M1)

(D2)

(M2)


OR

1.8

1.5

MAF

10%

10%

40%

40%


OR = odds ratio, MAF = minor allele frequency, LD = linkage disequilibrium.

The LD between the disease loci and the corresponding marker loci is 0.8, and the two disease loci are in linkage equilibrium.

Wang and Shete BMC Genetics 2011 12:3   doi:10.1186/1471-2156-12-3

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