Table 4

Type I error associated with the test for association between LV ejection fraction and the 96 AIMs

Control variable

Average

Type I error

Standard

error

Observed minimum

Type I error

Observed maximum

Type I error


Individual admixture estimates

0.038

0.0058

0.021

0.042


Principal components

0.048

0.007

0.021

0.052


Self-reported Ethnicity

0.042

0.004

0.031

0.053


Ignoring confounding

0.705

0.009

0.694

0.737


Note that when the confounding effect is ignored the type I error is about 14 times the nominal rate. However, controlling for Self-reported ethnicity alone in this case is sufficient to keep the type I error rate at its nominal value.

Divers et al. BMC Genetics 2011 12:28   doi:10.1186/1471-2156-12-28

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