Table 3

Type I error rates of ZMTT(0), ZMTT(0.5), ZMTT(1), ZSGMS, ZSGME, ZMAX3 and <a onClick="popup('http://www.biomedcentral.com/1471-2156/11/91/mathml/M38','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/11/91/mathml/M38">View MathML</a> with 2 df for small sample size.

Scenario

α

ZMTT(0)

ZMTT(0.5)

ZMTT(1)

ZSGMS

ZSGME

ZMAX3

<a onClick="popup('http://www.biomedcentral.com/1471-2156/11/91/mathml/M38','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2156/11/91/mathml/M38">View MathML</a>


A*

0.05

0.0474

0.0501

0.0487

0.0493

0.0495

0.0452

0.0502

B*

0.0531

0.0479

0.0497

0.0480

0.0485

0.0462

0.0503

C*

0.0569

0.0526

0.0489

0.0507

0.0526

0.0516

0.0488

D*

0.0470

0.0480

0.0516

0.0482

0.0484

0.0488

0.0503

E*

0.0492

0.0498

0.0489

0.0518

0.0511

0.0535

0.0498

F*

0.0519

0.0503

0.0514

0.0535

0.0537

0.0486

0.0489

G*

0.0484

0.0505

0.0526

0.0483

0.0466

0.0551

0.0502

H*

0.0504

0.0453

0.0451

0.0451

0.0456

0.0484

0.0504

A*

0.01

0.0076

0.0083

0.0092

0.0102

0.0089

0.0108

0.0126

B*

0.0075

0.0091

0.0097

0.0078

0.0088

0.0086

0.0081

C*

0.0078

0.0089

0.0096

0.0082

0.0084

0.0126

0.0092

D*

0.0080

0.0095

0.0116

0.0093

0.0092

0.0111

0.0099

E*

0.0072

0.0093

0.0098

0.0099

0.0092

0.0091

0.0120

F*

0.0087

0.0081

0.0089

0.0085

0.0081

0.0091

0.0116

G*

0.0077

0.0120

0.0120

0.0113

0.0125

0.0081

0.0102

H*

0.0079

0.0087

0.0088

0.0073

0.0081

0.0098

0.0095


The results are simulated based on 10,000 replicates in the presence of confounding factors with the significance level α using R cases and S controls.

A*: R = (15, 15, 20), S = (30, 30, 40), P = (0.1, 0.3, 0.5), K = (0.01, 0.05, 0.02)

B*: R = (10, 30, 10), S = (20, 60, 20), P = (0.1, 0.3, 0.5), K = (0.01, 0.05, 0.02)

C*: R = (30, 30, 40), S = (30, 30, 40), P = (0.1, 0.3, 0.5), K = (0.01, 0.05, 0.02)

D*: R = (20, 60, 20), S = (20, 60, 20), P = (0.1, 0.3, 0.5), K = (0.01, 0.05, 0.02)

E*: R = (25, 25), S = (50, 50), P = (0.2, 0.4), K = (0.01, 0.02)

F*: R = (15, 35), S = (30, 70), P = (0.2, 0.4), K = (0.01, 0.02)

G*: R = (50, 50), S = (50, 50), P = (0.2, 0.4), K = (0.01, 0.02)

H*: R = (30, 70), S = (30, 70), P = (0.2, 0.4), K = (0.01, 0.02)

Zang and Fung BMC Genetics 2010 11:91   doi:10.1186/1471-2156-11-91

Open Data