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Open Access Research article

A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice

Larry J Leamy1*, Daniel Pomp2345 and J Timothy Lightfoot6

Author Affiliations

1 Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA

2 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA

3 Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA

4 Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599, USA

5 Carolina Center for Genome Science, University of North Carolina, Chapel Hill, NC 27599, USA

6 Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77845, USA

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BMC Genetics 2010, 11:83  doi:10.1186/1471-2156-11-83

Published: 21 September 2010

Additional files

Additional file 1:

Basic statistics for the activity traits. Shown are the means and standard deviations (Std) of distance (km/day), duration (min/day) and speed (meters/min) during each of the seven time intervals (1-7). The sample size = 310 in all cases.

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Additional file 2:

Correlations and principal components analyses for the activity traits. Correlations are given for distance, duration, and speed traits for each of the 7 time intervals as well as loadings on the first two principal components, I and II, derived from a component analysis of the correlation matrix for each of the three traits.

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Additional file 3:

QTLs for distance. Shown are the locations, confidence intervals (CI), LPR scores (log10Prob-1), percentage of the total phenotypic variation explained (%), and standardized additive (a) and dominance genotypic values (d) for QTLs on all chromosomes affecting distance in any of the 7 time intervals (DT1 through DT7). Each QTL for distance is designated DIST followed by its chromosome number and an extension to indicate whether it is the first or second QTL on that chromosome. Subscripts are given for QTLs if they affect only males (M) or only females (F). Locations are given as map distances from the nearest proximal marker (Marker Dist) and from the centromere (Cent. Dist) and confidence intervals are expressed as distances from the centromere. Single locations and confidence intervals are indicated for multiple traits when tests suggested pleiotropy of common QTLs. All LPR values are significant at the 5% chromosomewise level or at the genomewise level (†). * = P < 0.05; ** = P < 0.01.

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Additional file 4:

QTLs for duration. Shown are the locations, confidence intervals (CI), LPR scores (log10Prob-1), percentage of the total phenotypic variation explained (%), and standardized additive (a) and dominance genotypic values (d) for QTLs on all chromosomes affecting duration in any of the 7 time intervals (DR1 through DR7). Each QTL is designated DUR followed by its chromosome number and an extension to indicate whether it is the first or second QTL on that chromosome. Subscripts are given for QTLs if they affect only males (M) or only females (F). Locations are given as map distances from the nearest proximal marker (Marker Dist) and from the centromere (Cent. Dist) and confidence intervals are expressed as distances from the centromere. Single locations and confidence intervals are indicated for multiple traits when tests suggested pleiotropy of common QTLs. All LPR values are significant at the 5% chromosomewise level or at the genomewise level (†). * = P < 0.05; ** = P < 0.01.

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Additional file 5:

QTLs for speed. Shown are the locations, confidence intervals (CI), LPR scores (log10Prob-1), percentage of the total phenotypic variation explained (%), and standardized additive (a) and dominance genotypic values (d) for QTLs on all chromosomes affecting speed in any of the 7 time intervals (SP1 through SP7). Each QTL is designated SPD followed by its chromosome number and an extension to indicate whether it is the first or second QTL on that chromosome. Subscripts are given for QTLs if they affect only males (M) or only females (F). Locations are given as map distances from the nearest proximal marker (Marker Dist) and from the centromere (Cent. Dist) and confidence intervals are expressed as distances from the centromere. Single locations and confidence intervals are indicated for multiple traits when tests suggested pleiotropy of common QTLs. All LPR values are significant at the 5% chromosomewise level or at the genomewise level (†). * = P < 0.05; ** = P < 0.01.

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Open Data

Additional file 6:

QTL summary statistics for the activity traits over the seven time intervals. Shown are the number of QTLs affecting the activity traits over each of the seven time intervals, the percentage of the total phenotypic variation they contribute (expressed as a total and per QTL), and the means of their absolute additive (a) and dominance genotypic values (d).

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Additional file 7:

QTLs for the slopes of the activity traits over all seven intervals. Shown are the locations, confidence intervals (CI), LPR scores (log10Prob-1), percentage of the total phenotypic variation explained (%), and standardized additive (a) and dominance genotypic values (d) for QTLs on all chromosomes affecting the regression (slope) of distance, duration, and speed over all intervals. Each QTL for distance is designated DISTB, DURB, or SPDB (for the slopes of distance, duration, and speed) followed by its chromosome number and an extension to indicate whether it is the first or second QTL on that chromosome. Subscripts are given for QTLs if they affect only males (M) or only females (F). Locations are given as map distances from the nearest proximal marker (Marker Dist) and from the centromere (Cent. Dist) and confidence intervals are expressed as distances from the centromere. Single locations and confidence intervals are indicated for multiple traits when tests suggested pleiotropy of common QTLs. All LPR values are significant at the 5% chromosomewise level or at the genomewise level (†). * = P < 0.05; ** = P < 0.01.

Format: PDF Size: 9KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data