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Open Access Highly Accessed Research article

Microsatellite-based genetic diversity and population structure of domestic sheep in northern Eurasia

Miika Tapio1, Mikhail Ozerov1, Ilma Tapio1, Miguel A Toro2, Nurbiy Marzanov3, Mirjana Ćinkulov4, Galina Goncharenko5, Tatyana Kiselyova6, Maziek Murawski7 and Juha Kantanen1*

Author Affiliations

1 Biotechnology and Food Research, MTT Agrifood Research Finland, 31600 Jokioinen, Finland

2 Departamento de Produccion Animal, Universidad Politecnica de Madrid, 28040 Madrid, Spain

3 All-Russian Research Institute of Animal Husbandry, Russian Academy of Agricultural Sciences, 142132 Moscow Region, Dubrovitsy, Russia

4 Animal Science Department, University of Novi Sad, 2100 Novi Sad, Serbia

5 Siberian Branch of Russian Academy of Agricultural Science, 630501 Novosibirsk Region, Krasnoobsk, Russia

6 All-Russian Research Institute of Animal Genetics and Breeding, Russian Academy of Agricultural Sciences, 189620 St. Petersburg-Pushkin, Russia

7 Department of Sheep and Goat Breeding, Agricultural University of Cracow, 31059 Cracow, Poland

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BMC Genetics 2010, 11:76  doi:10.1186/1471-2156-11-76

Published: 10 August 2010

Abstract

Background

Identification of global livestock diversity hotspots and their importance in diversity maintenance is essential for making global conservation efforts. We screened 52 sheep breeds from the Eurasian subcontinent with 20 microsatellite markers. By estimating and weighting differently within- and between-breed genetic variation our aims were to identify genetic diversity hotspots and prioritize the importance of each breed for conservation, respectively. In addition we estimated how important within-species diversity hotspots are in livestock conservation.

Results

Bayesian clustering analysis revealed three genetic clusters, termed Nordic, Composite and Fat-tailed. Southern breeds from close to the region of sheep domestication were more variable, but less genetically differentiated compared with more northern populations. Decreasing weight for within-breed diversity component led to very high representation of genetic clusters or regions containing more diverged breeds, but did not increase phenotypic diversity among the high ranked breeds. Sampling populations throughout 14 regional groups was suggested for maximized total genetic diversity.

Conclusions

During initial steps of establishing a livestock conservation program populations from the diversity hot-spot area are the most important ones, but for the full design our results suggested that approximately equal population presentation across environments should be considered. Even in this case, higher per population emphasis in areas of high diversity is appropriate. The analysis was based on neutral data, but we have no reason to think the general trend is limited to this type of data. However, a comprehensive valuation of populations should balance production systems, phenotypic traits and available genetic information, and include consideration of probability of success.