Table 3

Population Caucasian allele frequencies stratified by self reported region of ancestry

Gene

Polymorphism

Allele

(MA)

White

Caucasian

MAF

(95% CI)

British and Irish Isles

MAF

(95% CI)

Eastern Europe

MAF

(95% CI)

Germany

MAF

(95% CI)

Scandinavia

MAF

(95% CI)

P value


LEPR

rs1137101

G(A)

0.544

(0.539-0.549)

0.554

(0.536-0.572)

0.523

(0.498-0.548)

0.544

(0.536-0.552)

0.500

(0.473-0.527)

0.032

RNASEL

rs486907

G(A)

0.379

(0.374-0.384)

0.363

(0.345-0.381)

0.381

(0.357-0.405)

0.384

(0.377-0.391)

0.376

(0.350-0.402)

0.553

APOB

rs1042031

G(A)

0.18

(0.176-0.184)

0.190

(0.176-0.204)

0.179

(0.160-0.198)

0.184

(0.178-0.190)

0.153

(0.133-0.173)

0.143

CTLA4

rs231775

A(G)

0.386

(0.381-0.391)

0.394

(0.376-0.412)

0.422

(0.397-0.447)

0.373

(0.366-0.380)

0.422

(0.395-0.449)

<0.0001

AGTR1

rs5186

A(C)

0.299

(0.294-0.304)

0.298

(0.281-0.315)

0.285

(0.263-0.307)

0.305

(0.298-0.312)

0.278

(0.254-0.302)

0.185

DRD3

rs6280

T(C)

0.311

(0.306-0.316)

0.342

(0.325-0.359)

0.270

(0.248-0.292)

0.316

(0.309-0.323)

0.306

(0.281-0.331)

0.0001

FABP2

rs1799883

G(A)

0.261

(0.257-0.265)

0.261

(0.245-0.277)

0.258

(0.236-0.280)

0.261

(0.254-0.268)

0.271

(0.247-0.295)

0.871

ADD1

rs4961

G(T)

0.191

(0.187-0.195)

0.188

(0.174-0.202)

0.165

(0.147-0.183)

0.192

(0.186-0.198)

0.197

(0.175-0.219)

0.158

ADRB2

rs1042714

C(G)

0.433

(0.428-0.438)

0.457

(0.439-0.475)

0.403

(0.379-0.427)

0.428

(0.420-0.436)

0.419

(0.392-0.446)

0.0018

FGFR4

rs351855

C(T)

0.303

(0.298-0.308)

0.286

(0.269-0.303)

0.351

(0.327-0.375)

0.299

(0.292-0.306)

0.330

(0.304-0.356)

<0.0001

EDN1

rs5370

G(T)

0.214

(0.210-0.218)

0.218

(0.203-0.233)

0.193

(0.173-0.213)

0.210

(0.204-0.216)

0.201

(0.179-0.223)

0.524

HTR1B

rs6296

G(C)

0.268

(0.264-0.272)

0.266

(0.250-0.282)

0.281

(0.259-0.303)

0.264

(0.257-0.271)

0.290

(0.265-0.315)

0.045

EGFR

rs2227983

G(A)

0.253

(0.249-0.257)

0.265

(0.249-0.281)

0.260

(0.238-0.282)

0.250

(0.243-0.257)

0.260

(0.236-0.284)

0.209

CFTR

rs213950

G(A)

0.426

(0.421-0.431)

0.423

(0.405-0.441)

0.444

(0.419-0.469)

0.427

(0.419-0.435)

0.424

(0.397-0.451)

0.085

PON2

rs7493

C(G)

0.244

(0.240-0.248)

0.252

(0.236-0.268)

0.279

(0.257-0.301)

0.239

(0.233-0.245)

0.257

(0.233-0.281)

0.004

LPL

rs328

C(G)

0.098

(0.095-0.101)

0.099

(0.088-0.110)

0.092

(0.078-0.106)

0.099

(0.094-0.104)

0.090

(0.074-0.106)

0.682

9p21

rs2383206

A(G)

0.499

(0.494-0.504)

0.522

(0.504-0.540)

0.496

(0.471-0.521)

0.495

(0.487-0.503)

0.477

(0.450-0.504)

0.150

RET

rs1800861

A(C)

0.232

(0.228-0.236)

0.213

(0.198-0.228)

0.256

(0.234-0.278)

0.240

(0.234-0.246)

0.203

(0.181-0.225)

0.001

ADRB1

rs1801253

C(G)

0.271

(0.267-0.275)

0.264

(0.248-0.280)

0.269

(0.247-0.291)

0.270

(0.263-0.277)

0.275

(0.251-0.299)

0.922

PLAU

rs2227564

C(T)

0.247

(0.243-0.251)

0.239

(0.223-0.255)

0.219

(0.198-0.240)

0.244

(0.237-0.251)

0.277

(0.253-0.301)

0.012

MMP1

rs1799750

-(G)

0.469

(0.464-0.474)

0.486

(0.468-0.504)

0.458

(0.433-0.483)

0.460

(0.452-0.468)

0.505

(0.478-0.532)

0.020

VWF

rs1063856

A(G)

0.361

(0.356-0.366)

0.381

(0.363-0.399)

0.337

(0.314-0.360)

0.353

(0.346-0.360)

0.372

(0.346-0.398)

0.006

HTR2A

rs6313

C(T)

0.406

(0.401-0.411)

0.400

(0.382-0.418)

0.370

(0.346-0.394)

0.412

(0.405-0.419)

0.397

(0.370-0.424)

0.071

MTHFD1

rs2236225

C(T)

0.447

(0.442-0.452)

0.456

(0.438-0.474)

0.442

(0.417-0.467)

0.446

(0.438-0.454)

0.439

(0.412-0.466)

0.792

LIPC

rs1800588

C(T)

0.214

(0.210-0.218)

0.225

(0.210-0.240)

0.232

(0.211-0.253)

0.213

(0.207-0.219)

0.212

(0.190-0.234)

0.077

MMP2

rs243865

C(T)

0.247

(0.243-0.251)

0.242

(0.226-0.258)

0.257

(0.235-0.279)

0.243

(0.236-0.250)

0.248

(0.225-0.271)

0.888

CYBA

rs4673

C(T)

0.341

(0.336-0.346)

0.318

(0.301-0.335)

0.365

(0.341-0.389)

0.338

(0.331-0.345)

0.325

(0.300-0.350)

0.083

CETP

rs708272

C(T)

0.422

(0.417-0.427)

0.436

(0.418-0.454)

0.409

(0.385-0.433)

0.420

(0.413-0.427)

0.436

(0.409-0.463)

0.027

ELAC2

rs4792311

G(A)

0.304

(0.299-0.309)

0.291

(0.274-0.308)

0.304

(0.281-0.327)

0.309

(0.302-0.316)

0.292

(0.267-0.317)

0.492

ENOSF1/TYMS

rs16430

+(-)

0.297

(0.292-0.302)

0.301

(0.284-0.318)

0.273

(0.251-0.295)

0.300

(0.293-0.307)

0.305

(0.280-0.330)

0.314

FUT2

rs601338

G(A)

0.456

(0.451-0.461)

0.486

(0.468-0.504)

0.394

(0.370-0.418)

0.452

(0.444-0.460)

0.502

(0.475-0.529)

<0.0001

LDLR

rs688

C(T)

0.423

(0.418-0.428)

0.443

(0.425-0.461)

0.406

(0.382-0.430)

0.421

(0.414-0.428)

0.420

(0.393-0.447)

0.038

GNAS

rs7121

C(T)

0.477

(0.472-0.482)

0.500

(0.482-0.518)

0.468

(0.443-0.493)

0.475

(0.467-0.483)

0.473

(0.446-0.500)

0.317

CBS

rs234706

G(A)

0.348

(0.343-0.353)

0.342

(0.325-0.359)

0.331

(0.308-0.354)

0.347

(0.340-0.354)

0.344

(0.318-0.370)

0.266

IL1B

rs16944

G(A)

0.329

(0.324-0.334)

0.343

(0.326-0.360)

0.326

(0.303-0.349)

0.332

(0.325-0.339)

0.312

(0.287-0.337)

0.170

NOS3

rs1799983

G(T)

0.308

(0.303-0.313)

0.318

(0.301-0.335)

0.287

(0.265-0.309)

0.309

(0.302-0.316)

0.296

(0.271-0.321)

0.420

TGFB1

rs1800469

C(T)

0.306

(0.301-0.311)

0.299

(0.282-0.316)

0.320

(0.297-0.343)

0.309

(0.302-0.316)

0.296

(0.271-0.321)

0.742

TNFa

rs1800629

G(A)

0.171

(0.167-0.175)

0.189

(0.175-0.203)

0.156

(0.138-0.174)

0.169

(0.163-0.175)

0.172

(0.152-0.192)

0.009

IL6

rs1800795

G(C)

0.440

(0.435-0.445)

0.430

(0.412-0.448)

0.453

(0.428-0.478)

0.438

(0.430-0.446)

0.455

(0.428-0.482)

0.200

IL6

rs1800796

G(C)

0.052

(0.050-0.054)

0.055

(0.047-0.063)

0.063

(0.051-0.075)

0.051

(0.048-0.054)

0.045

(0.034-0.056)

0.108

IL10

rs1800872

C(A)

0.240

(0.236-0.244)

0.236

(0.220-0.252)

0.242

(0.221-0.263)

0.240

(0.234-0.246)

0.244

(0.221-0.267)

0.551

MTHFR

rs1801133

C(T)

0.327

(0.322-0.332)

0.322

(0.305-0.339)

0.307

(0.284-0.330)

0.327

(0.320-0.334)

0.325

(0.300-0.350)

0.677

LPL

rs268

A(G)

0.020

(0.019-0.021)

0.020

(0.015-0.025)

0.017

(0.011-0.023)

0.021

(0.019-0.023)

0.032

(0.022-0.042)

0.034

ACE

rs4291

A(T)

0.377

(0.372-0.382)

0.377

(0.359-0.395)

0.373

(0.349-0.397)

0.379

(0.372-0.386)

0.379

(0.353-0.405)

0.879

ACE

rs4343

G(A)

0.479

(0.474-0.484)

0.480

(0.462-0.498)

0.506

(0.481-0.531)

0.476

(0.468-0.484)

0.488

(0.461-0.515)

0.009

APOE

rs429358

T(C)

0.145

(0.141-0.149)

0.151

(0.138-0.164)

0.117

(0.101-0.133)

0.138

(0.133-0.143)

0.182

(0.161-0.203)

<0.0001

APOE

rs7412

C(T)

0.083

(0.080-0.086)

0.077

(0.067-0.087)

0.082

(0.068-0.096)

0.089

(0.085-0.093)

0.076

(0.062-0.090)

0.299

COMT

rs4680

A(G)

0.466

(0.461-0.471)

0.470

(0.452-0.488)

0.484

(0.459-0.509)

0.467

(0.459-0.475)

0.421

(0.394-0.448)

0.009

VDR

rs7975232

A(C)

0.483

(0.478-0.488)

0.481

(0.463-0.499)

0.491

(0.466-0.516)

0.488

(0.480-0.496)

0.468

(0.441-0.495)

0.113

VDR

rs731236

T(C)

0.387

(0.382-0.392)

0.380

(0.362-0.398)

0.365

(0.341-0.389)

0.382

(0.375-0.389)

0.384

(0.358-0.410)

0.284

VDR

rs1544410

G(A)

0.392

(0.387-0.397)

0.387

(0.369-0.405)

0.368

(0.344-0.392)

0.387

(0.380-0.394)

0.387

(0.361-0.413)

0.479


Cross et al. BMC Genetics 2010 11:51   doi:10.1186/1471-2156-11-51

Open Data