Table 2

Population allele frequencies stratified by self reported race

Gene

Polymorphism

Allele

(MA)

Population

MAF

(95% CI)

White/

Caucasian

MAF

(95% CI)

White

Hispanic

MAF

(95% CI)

Black

African American

MAF

(95% CI)

Asian

Hmong

MAF

(95% CI)

American

Indian

MAF

(95% CI)

P value


LEPR

rs1137101

G(A)

0.459

(0.454-0.464)

0.544

(0.539-0.549)

0.493

(0.445-0.541)

0.410

(0.314-0.506)

0.330

(0.263-0.397)

0.479

(0.425-0.533)

<0.0001

RNASEL

rs486907

G(A)

0.375

(0.370-0.380)

0.379

(0.374-0.384)

0.214

(0.174-0.254)

0.100

(0.041-0.159)

0.308

(0.242-0.374)

0.284

(0.236-0.332)

<0.0001

APOB

rs1042031

G(A)

0.180

(0.176-0.184)

0.18

(0.176-0.184)

0.167

(0.131-0.203)

0.220

(0.139-0.301)

0.063

(0.028-0.098)

0.182

(0.141-0.223)

0.0023

CTLA4

rs231775

A(G)

0.388

(0.383-0.393)

0.386

(0.381-0.391)

0.480

(0.432-0.528)

0.370

(0.275-0.465)

0.479

(0.408-0.550)

0.413

(0.360-0.466)

<0.0001

AGTR1

rs5186

A(C)

0.298

(0.293-0.303)

0.299

(0.294-0.304)

0.306

(0.262-0.350)

0.110

(0.049-0.171)

0.106

(0.062-0.150)

0.287

(0.238-0.336)

<0.0001

DRD3

rs6280

T(C)

0.315

(0.310-0.320)

0.311

(0.306-0.316)

0.480

(0.432-0.528)

0.240

(0.156-0.324)

0.297

(0.232-0.362)

0.359

(0.308-0.410)

<0.0001

FABP2

rs1799883

G(A)

0.262

(0.258-0.266)

0.261

(0.257-0.265)

0.293

(0.249-0.337)

0.240

(0.156-0.324)

0.250

(0.188-0.312)

0.295

(0.246-0.344)

0.3968

ADD1

rs4961

G(T)

0.192

(0.188-0.196)

0.191

(0.187-0.195)

0.209

(0.170-0.248)

0.100

(0.041-0.159)

0.346

(0.278-0.414)

0.165

(0.125-0.205)

<0.0001

ADRB2

rs1042714

C(G)

0.428

(0.423-0.433)

0.433

(0.428-0.438)

0.214

(0.174-0.254)

0.250

(0.165-0.335)

0.170

(0.116-0.224)

0.404

(0.351-0.457)

<0.0001

FGFR4

rs351855

C(T)

0.305

(0.300-0.310)

0.303

(0.298-0.308)

0.430

(0.382-0.478)

0.170

(0.096-0.244)

0.436

(0.365-0.507)

0.314

(0.264-0.364)

<0.0001

EDN1

rs5370

G(T)

0.213

(0.209-0.217)

0.214

(0.210-0.218)

0.182

(0.145-0.219)

0.180

(0.105-0.255)

0.255

(0.193-0.317)

0.165

(0.125-0.205)

0.0835

HTR1B

rs6296

G(C)

0.270

(0.266-0.274)

0.268

(0.264 -0.272)

0.391

(0.344-0.438)

0.220

(0.139-0.301)

0.367

(0.298-0.436)

0.320

(0.270-0.370)

<0.0001

EGFR

rs2227983

G(A)

0.255

(0.251-0.259)

0.253

(0.249-0.257)

0.313

(0.268-0.358)

0.090

(0.034-0.146)

0.527

(0.456-0.598)

0.275

(0.227-0.323)

<0.0001

CFTR

rs213950

G(A)

0.428

(0.423-0.433)

0.426

(0.421-0.431)

0.512

(0.464-0.560)

0.760

(0.676-0.844)

0.484

(0.413-0.555)

0.389

(0.337-0.441)

<0.0001

PON2

rs7493

C(G)

0.244

(0.240-0.248)

0.244

(0.240-0.248)

0.231

(0.190-0.272)

0.350

(0.257-0.443)

0.245

(0.184-0.306)

0.207

(0.164-0.250)

0.2519

LPL

rs328

C(G)

0.098

(0.095-0.101)

0.098

(0.095-0.101)

0.083

(0.056-0.110)

0.080

(0.027-0.133)

0.080

(0.041-0.119)

0.108

(0.075-0.141)

0.9200

9p21

rs2383206

A(G)

0.500

(0.495-0.505)

0.499

(0.494-0.504)

0.551

(0.503-0.599)

0.550

(0.452-0.648)

0.505

(0.434-0.576)

0.547

(0.494-0.600)

0.2803

RET

rs1800861

A(C)

0.233

(0.229-0.237)

0.232

(0.228-0.236)

0.218

(0.178-0.258)

0.130

(0.064-0.196)

0.452

(0.381-0.523)

0.219

(0.175-0.263)

<0.0001

ADRB1

rs1801253

C(G)

0.270

(0.266-0.274)

0.271

(0.267-0.275)

0.163

(0.127-0.199)

0.500

(0.402-0.598)

0.229

(0.169-0.289)

0.222

(0.177-0.267)

<0.0001

PLAU

rs2227564

C(T)

0.247

(0.243-0.251)

0.247

(0.243-0.251)

0.250

(0.208-0.292)

0.100

(0.041-0.159)

0.299

(0.234-0.364)

0.246

(0.200-0.292)

0.354

MMP1

rs1799750

-(G)

0.471

(0.466-0.476)

0.469

(0.464-0.474)

0.638

(0.592-0.684)

0.460

(0.362-0.558)

0.565

(0.494-0.636)

0.494

(0.440-0.548)

<0.0001

VWF

rs1063856

A(G)

0.359

(0.354-0.364)

0.361

(0.356-0.366)

0.250

(0.208-0.292)

0.490

(0.392-0.588)

0.170

(0.116-0.224)

0.290

(0.241-0.339)

<0.0001

HTR2A

rs6313

C(T)

0.406

(0.401-0.411)

0.406

(0.401-0.411)

0.369

(0.322-0.416)

0.350

(0.257-0.443)

0.450

(0.379-0.521)

0.392

(0.340-0.444)

0.3286

MTHFD1

rs2236225

C(T)

0.448

(0.443-0.453)

0.447

(0.442-0.452)

0.578

(0.530-0.626)

0.240

(0.156-0.324)

0.293

(0.228-0.358)

0.476

(0.422-0.530)

<0.0001

LIPC

rs1800588

C(T)

0.218

(0.214-0.222)

0.214

(0.210-0.218)

0.480

(0.432-0.528)

0.430

(0.333-0.527)

0.346

(0.278-0.414)

0.254

(0.207-0.301)

<0.0001

MMP2

rs243865

C(T)

0.246

(0.242-0.250)

0.247

(0.243-0.251)

0.218

(0.178-0.258)

0.100

(0.041-0.159)

0.112

(0.067-0.157)

0.257

(0.210-0.304)

<0.0001

CYBA

rs4673

C(T)

0.339

(0.334-0.344)

0.341

(0.336-0.346)

0.209

(0.170-0.248)

0.370

(0.275-0.465)

0.213

(0.154-0.272)

0.371

(0.319-0.423)

<0.0001

CETP

rs708272

C(T)

0.421

(0.416-0.426)

0.422

(0.417-0.427)

0.432

(0.384-0.480)

0.306

(0.216-0.396)

0.398

(0.328-0.468)

0.428

(0.375-0.481)

0.0924

ELAC2

rs4792311

G(A)

0.303

(0.298-0.308)

0.304

(0.299-0.309)

0.262

(0.220-0.304)

0.280

(0.192-0.368)

0.165

(0.112-0.218)

0.317

(0.267-0.367)

<0.0001

ENOSF1/TYMS

rs16430

+(-)

0.299

(0.294-0.304)

0.297

(0.292-0.302)

0.347

(0.301-0.393)

0.470

(0.372-0.568)

0.585

(0.515-0.655)

0.293

(0.244-0.342)

<0.0001

FUT2

rs601338

G(A)

0.456

(0.451-0.461)

0.267

(0.224-0.310)

0.500

(0.402-0.598)

0.133

(0.084-0.182)

0.410

(0.357-0.463)

<0.0001

LDLR

rs688

C(T)

0.422

(0.417-0.427)

0.423

(0.418-0.428)

0.425

(0.377-0.473)

0.150

(0.080-0.220)

0.335

(0.268-0.402)

0.467

(0.413-0.521)

<0.0001

GNAS

rs7121

C(T)

0.480

(0.475-0.485)

0.477

(0.472-0.482)

0.575

(0.527-0.623)

0.700

(0.610-0.790)

0.606

(0.536-0.676)

0.545

(0.492-0.598)

<0.0001

CBS

rs234706

G(A)

0.345

(0.340-0.350)

0.348

(0.343-0.353)

0.233

(0.192-0.274)

0.220

(0.139-0.301)

0.118

(0.072-0.164)

0.335

(0.284-0.386)

<0.0001

IL1B

rs16944

G(A)

0.334

(0.329-0.339)

0.329

(0.324-0.334)

0.566

(0.518-0.614)

0.550

(0.452-0.648)

0.500

(0.429-0.571)

0.437

(0.384-0.490)

<0.0001

NOS3

rs1799983

G(T)

0.306

(0.301-0.311)

0.308

(0.303-0.313)

0.228

(0.187-0.269)

0.130

(0.064-0.196)

0.149

(0.098-0.200)

0.263

(0.216-0.310)

<0.0001

TGFB1

rs1800469

C(T)

0.308

(0.303-0.313)

0.306

(0.301-0.311)

0.468

(0.420-0.516)

0.250

(0.165-0.335)

0.410

(0.340-0.480)

0.287

(0.238-0.336)

<0.0001

TNFa

rs1800629

G(A)

0.170

(0.166-0.174)

0.171

(0.167-0.175)

0.083

(0.056-0.110)

0.160

(0.088-0.232)

0.080

(0.041-0.119)

0.132

(0.096-0.168)

<0.0001

IL6

rs1800795

G(C)

0.434

(0.429-0.439)

0.440

(0.435-0.445)

0.199

(0.160-0.238)

0.160

(0.088-0.232)

0.085

(0.045-0.125)

0.326

(0.276-0.376)

<0.0001

IL6

rs1800796

G(C)

0.057

(0.055-0.059)

0.052

(0.050-0.054)

0.260

(0.218-0.302)

0.110

(0.049-0.171)

0.479

(0.408-0.550)

0.111

(0.077-0.145)

<0.0001

IL10

rs1800872

C(A)

0.244

(0.240-0.248)

0.240

(0.236-0.244)

0.362

(0.316-0.408)

0.350

(0.257-0.443)

0.553

(0.482-0.624)

0.269

(0.221-0.317)

<0.0001

MTHFR

rs1801133

C(T)

0.327

(0.322-0.332)

0.327

(0.322-0.332)

0.485

(0.437-0.533)

0.100

(0.041-0.159)

0.229

(0.169-0.289)

0.344

(0.293-0.395)

<0.0001

LPL

rs268

A(G)

0.020

(0.019-0.021)

0.020

(0.019-0.021)

0.001

(0.000-0.004)

0

0

0.015

(0.002-0.028)

NA

ACE

rs4291

A(T)

0.377

(0.372-0.382)

0.389

(0.384-0.394)

0.415

(0.367-0.463)

0.347

(0.254-0.440)

0.316

(0.250-0.382)

0.377

(0.325-0.429)

0.2086

ACE

rs4343

G(A)

0.481

(0.476-0.486)

0.479

(0.474-0.484)

0.556

(0.508-0.604)

0.710

(0.621-0.799)

0.580

(0.509-0.651)

0.488

(0.434-0.542)

<0.0001

APOE

rs429358

T(C)

0.144

(0.141-0.147)

0.145

(0.141-0.149)

0.100

(0.071-0.129)

0.220

(0.139-0.301)

0.085

(0.045-0.125)

0.123

(0.088-0.158)

0.0108

APOE

rs7412

C(T)

0.083

(0.080-0.086)

0.083

(0.080-0.086)

0.030

(0.014-0.046)

0.140

(0.072-0.208)

0.060

(0.026-0.094)

0.084

(0.054-0.114)

0.0056

COMT

rs4680

A(G)

0.469

(0.464-0.474)

0.466

(0.461-0.471)

0.570

(0.522-0.618)

0.690

(0.599-0.781)

0.654

(0.586-0.722)

0.461

(0.408-0.514)

<0.0001

VDR

rs7975232

A(C)

0.485

(0.480-0.490)

0.483

(0.478-0.488)

0.573

(0.525-0.621)

0.410

(0.314-0.506)

0.633

(0.564-0.702)

0.500

(0.446-0.554)

<0.0001

VDR

rs731236

T(C)

0.384

(0.379-0.389)

0.387

(0.382-0.392)

0.245

(0.203-0.287)

0.320

(0.229-0.411)

0.165

(0.112-0.218)

0.359

(0.308-0.410)

<0.0001

VDR

rs1544410

G(A)

0.389

(0.384-0.394)

0.392

(0.387-0.397)

0.243

(0.202-0.284)

0.310

(0.219-0.401)

0.223

(0.163-0.283)

0.344

(0.293-0.395)

<0.0001


Cross et al. BMC Genetics 2010 11:51   doi:10.1186/1471-2156-11-51

Open Data