Table 4

Comparison of the risk of SCC of the oesophagus associated with different GST genotypes

Genotypes

Patients N(%)

Controls N(%)

OR (95%CI) p-value

Patients N(%)

Controls N(%)

OR (95%CI) p-value


GSTM1*0

GSTM1*1

GSTM1*1

98 (87)

65 (64)

1.00

108 (85)

135 (76)

1.00

GSTM1*0

15 (13)

37 (36)

0.27 (0.12-0.62) 0.002

19 (15)

43 (24)

0.36 (0.17-0.76) 0.008

GSTP1 313A/A

49 (43)

38 (37)

1.00

43 (34)

69 (39)

1.00

GSTP1 313 A/G

49 (44)

50 (49)

0.51 (0.25-1.05) 0.069

62 (49)

84 (47)

1.28 (0.69-3.37) 0.434

GSTP1 313G/G

15 (13)

14 (14)

0.42 (0.13-1.33) 0.139

22 (17)

25 (14)

2.36 (1.04-5.37) 0.041

GSTP1 341 C/C

70 (62)

94 (92)

1.00

80 (63)

158 (89)

1.00

GSTP1-341C/T + GSTP1-341T/T

43 (38)

8 (8)

14.9 (5.64-39.4) 0.001

47 (37)

20 (11)

3.76 (1.82-7.77) 0.001

GSTM1*0

GSTM1*1

GSTT1*1

19 (56)

43 (54)

1.00

108 (52)

135 (68)

1.00

GSTT1*0

15 (44)

37 (46)

0.73 (0.25-2.10) 0.559

98 (48)

65 (32)

1.55 (093-2.58) 0.093

GSTP1 313A/A

13 (38)

32 (40)

1.00

79 (38)

75 (37)

1.00

GSTP1 313 A/G

15 (44)

39 (49)

1.63 (0.52-5.12) 0.40

96 (47)

95 (48)

0.80 (0.47-1.36) 0.417

GSTP1 313G/G

6 (18)

9 (11)

2.78 (0.59-13.0) 0.193

31 (15)

30 (15)

1.04 (0.50-2.19) 0.914

GSTP1 341 C/C

22 (65)

73 (91)

1.00

128 (62)

179 (90)

1.00

GSTP1-341C/T + GSTP1-341T/T

12 (35)

7 (9)

6.06 (1.79-20.5) 0.004

78 (38)

21 (10)

6.31 (3.26-12.2) 0.001


OR, odds ratios adjusted for age, sex, race, tobacco smoking, alcohol consumption and use of charcoal or wood for cooking. *1 signifies carrier of gene, *0 signifies homozygous gene deletion.

Li et al. BMC Genetics 2010 11:47   doi:10.1186/1471-2156-11-47

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