Table 3

QTL results of genome-wide scans for social interaction QTL in NC900 × B6 F2 mice.

Traits

MMU

PEAK (cM)

LOD

CI

Additivea(± s.e.)

Dominanceb(± s.e.)

% Variation


attack latency

7

49.85

3.10

36.95 - 59.25

-34.09 (± 43.15)

189.30 (± 53.13)

15.91

attack

19

35.46

3.65*

7.76 - 47.36

-12.86 (± 3.51)

-12.10 (± 5.29)

19.21

aggression count

19

35.96

3.41*

20.56 - 48.86

-3.58 (± 1.02)

-2.93 (± 1.56)

17.95


% total social duration

4

26.92

3.12

21.38 - 56.38

2.06 (± 1.90)

-10.00 (± 2.90)

16.49

% affilliative duration

4

30.38

3.32*

37.80 - 56.60

3.81 (± 2.00)

-9.19 (± 3.01)

17.63

approach count

7

51.35

3.22*

40.55 - 59.64

-0.06 (± 0.80)

3.74 (± 1.04)

15.64

% approach duration

14

43.50

2.94

37.80 - 56.60

0.62 (± 0.31)

1.21 (± 0.44)

15.04

affilliative count

19

7.76

3.03

0 - 36.18

4.31 (± 1.57)

-8.97 (± 2.64)

16.00

% bidirectional duration

19

7.76

3.20

0 - 15.26

0.87 (± 0.35)

-2.03 (± 0.59)

17.18

bidirectional count

19

7.76

3.52*

0 - 18.95

0.53 (± 0.43)

-2.52 (± 0.74)

18.84

% aggression duration

19

35.36

3.66*

20.46 - 47.46

-7.15 (± 1.55)

-6.40 (± 2.99)

17.90


Superscript * indicates LOD exceeding 95th percentile LOD permutation threshold. Others exceed the 90th percentile.

aAdditive effect; a positive value indicates that the increasing allele comes from NC900.

bDominance effect; in relation to the heterozygous genotype and mean of the two homozygous genotype: a positive value indicates that the heterozygote is larger than the midparent (mean of the parents).

Nehrenberg et al. BMC Genetics 2010 11:113   doi:10.1186/1471-2156-11-113

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