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Open Access Research article

Genomic regions associated with kyphosis in swine

Amanda K Lindholm-Perry1*, Gary A Rohrer1, Larry A Kuehn1, John W Keele1, Justin W Holl2, Steven D Shackelford1, Tommy L Wheeler1 and Dan J Nonneman1

Author Affiliations

1 USDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE 68933-0166, USA

2 Smithfield Premium Genetics Group, Rose Hill, NC 28458, USA

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BMC Genetics 2010, 11:112  doi:10.1186/1471-2156-11-112

Published: 21 December 2010

Abstract

Background

A back curvature defect similar to kyphosis in humans has been observed in swine herds. The defect ranges from mild to severe curvature of the thoracic vertebrate in split carcasses and has an estimated heritability of 0.3. The objective of this study was to identify genomic regions that affect this trait.

Results

Single nucleotide polymorphism (SNP) associations performed with 198 SNPs and microsatellite markers in a Duroc-Landrace-Yorkshire resource population (U.S. Meat Animal Research Center, USMARC resource population) of swine provided regions of association with this trait on 15 chromosomes. Positional candidate genes, especially those involved in human skeletal development pathways, were selected for SNP identification. SNPs in 16 candidate genes were genotyped in an F2 population (n = 371) and the USMARC resource herd (n = 1,257) with kyphosis scores. SNPs in KCNN2 on SSC2, RYR1 and PLOD1 on SSC6 and MYST4 on SSC14 were significantly associated with kyphosis in the resource population of swine (P ≤ 0.05). SNPs in CER1 and CDH7 on SSC1, PSMA5 on SSC4, HOXC6 and HOXC8 on SSC5, ADAMTS18 on SSC6 and SOX9 on SSC12 were significantly associated with the kyphosis trait in the F2 population of swine (P ≤ 0.05).

Conclusions

These data suggest that this kyphosis trait may be affected by several loci and that these may differ by population. Carcass value could be improved by effectively removing this undesirable trait from pig populations.