Frequency of rs405509 in Centenarians in 8 Clusters. The allele frequencies of rs4005509, a SNP near APOE, vary greatly between the 8 clusters of centenarians identified in the analysis of the NECS and Illumina subjects. The odds ratio for each cluster is calculated using a separate logistic regression model of exceptional longevity and the SNP genotype coded as the number of A alleles. The odds ratios are quite different among various ethnic groups indicating that APOE may have a different impact in different ethnic groups.
Solovieff et al. BMC Genetics 2010 11:108 doi:10.1186/1471-2156-11-108