Table 3

Associations between SNP alleles with minor allele frequencies and quantitative measures of the hair colours (L*a*b* values) with P < 0.05 in 107 Scots from Edinburgh.

Gene

Chr.

Positiona

SNP

Min.

allele

MAFb

L*

p-value

L*

R2

a*

p-value

a*

R2

b*

p-value

b*

R2

Hair colour


HPS3

3

Int 1.1

rs4681169

A

0.30

0.046

0.039

Dark

Int 1.2

rs16861514

T

0.15

0.043

0.039

Dark

Int 6

rs16861552

C

0.33

0.021

0.054

Dark

Int 8

rs6785780

T

0.41

0.003

0.079

Red/Light

Int 13

rs7636389

A

0.07

0.026

0.049

Red/Light


DTNBP1

6

Exon 10

(S272P)

rs17470454

A

0.05

0.011

0.060

0.011

0.044

Light


TYRP1

9

Int 6

rs17346161

T

0.06

0.046

0.037

Red/Light


ERCC6

10

Int 5

rs1018603

C

0.11

0.041

0.041

0.041

0.038

Dark


Int 9

rs4253162

A

0.07

0.011

0.058

0.011

0.060

Dark


KITLG

12

Int 1.1

rs1492354

A

0.07

0.0009d

0.119

Red/Light

Int 1.2

rs1907702

G

0.20

0.018

0.05

Red/Light

Int 1.3

rs10777129

A

0.08

0.007

0.06

0.043

0.080

Red/Light



OCA2

15

Int 1.1

rs7495174

G

0.05

0.02

0.051

0.024

0.040

Dark

Int 1.2

rs7174027

A

0.06

0.005

0.075

0.005

0.060

Dark


Int 2.1

rs12442147

C

0.11

0.03

0.041

0.010

0.066

0.03

0.065

Dark

Int 2.2

rs12324648

A

0.07

0.019

0.057

Dark

Int 2.3

rs1470608

A

0.10

0.012

0.063

Dark


Int 4

rs3794604

A

0.08

0.031

0.042

Dark


Int 5

rs749846

A

0.11

0.025

0.054

Dark


Int 19

rs1375166

A

0.20

0.046

0.039

Dark


Int 23.1

rs2311470

C

0.50

0.005

0.073

Dark

Int 23.2

rs11858340

A

0.44

0.016

0.053

Red/Light

Int 23.3

rs6497235

A

0.50

0.03

0.050

0.006

0.069

0.03

0.063

Light

Int 23.4

rs11074306

A

0.41

0.024

0.048

Dark

Int 23.5

rs6497233

T

0.41

0.02

0.053

0.0004e

0.116

0.021

0.098

Light

Int 23.6

rs17674017

G

0.42

0.005

0.073

Red/Light

Int 23.7

rs1498509

C

0.49

0.010

0.060

Dark

Int 23.8

rs11631195

A

0.37

0.004

0.079

0.0002d

0.126

0.0037c

0.130

Light

Int 23.9

rs3947367

G

0.29

0.012

0.059

0.012

0.039

Light

Int 23.10

rs11637518

G

0.35

0.014

0.051

0.009

0.064

0.014

0.078

Light

Int 23.11

rs989869

C

0.38

0.008

0.063

0.0077

0.053

Dark

Int 23.12

rs1603784

A

0.23

0.007

0.063

0.0069

0.041

Dark



MYO05

15

Int 1.1

rs1615028

C

0.17

0.046

0.037

Light

Int 1.2

rs1724593

G

0.15

0.012

0.059

0.012

0.066

Light

Int 1.3

rs7176061

C

0.48

0.046

0.041

Dark


Int 2

rs1724625

T

0.30

0.036

0.044

Light


Int 5

rs1724630

G

0.21

0.049

0.039

0.049

0.040

Light


Int 9

rs1632403

T

0.08

0.042

0.039

0.042

0.049

Light


MC1R

16

Exon

R

None

0.21

2.00 × 10-6c

0.317

0.047c

0.156

Red

Exon

r

None

0.23

0.005

0.07

Dark/Light


PRKAR1A

17

Int 2

rs2952275

T

0.36

0.047

0.036

Light


5' UTR

rs8080306

C

0.27

0.021

0.047

Light


GNAS

20

Int 3

rs2295583

T

0.28

0.03

0.43

Light


Int 5

rs3730168

A

0.41

0.015

0.052

Dark


Int 6

rs919197

T

0.43

0.006

0.07

0.0062

0.059

Light


HPS4

22

Int 2

rs9613187

T

0.11

0.012

0.059

0.012

0.037

Light


Int 5

rs17401652

T

0.10

0.028

0.047

Red/Light


a: Intron (Int), Exon or Untranslated region (UTR) position in the gene

b: Minor allele frequency (MAF)

c: Significant using Bonferroni correction. Other L*, a* and b* values were corrected using empirical permutations

d: Significant using False Discovery Rate correction

Mengel-From et al. BMC Genetics 2009 10:88   doi:10.1186/1471-2156-10-88

Open Data