Table 7 

Epistatic model  mixed (EPI RD). 

Low risk 
High risk 

r_{1 }= 2; r_{2 }= 4 
r_{1 }= 5; r_{2 }= 10 



Theoretical penetrance matrix 



Neural network 

Mean absolute difference E 

Sum 
0.2239 
0.1563 


Logistic regression 

Mean absolute difference E 

Sum 
0.5105 
0.8658 


Logistic regression (design variables) 

Mean absolute difference E 

Sum 
0.2799 
0.2329 


Mean absolute differences between theoretical and estimated penetrance matrices from 100 replications in the low and high risk scenario. 

Günther et al. BMC Genetics 2009 10:87 doi:10.1186/147121561087 