Table 6 

Epistatic model  dominant (EPI DD). 

Low risk 
High risk 

r_{1 }= 2; r_{2 }= 4 
r_{1 }= 5; r_{2 }= 10 



Theoretical penetrance matrix 



Neural network 

Mean absolute difference E 

Sum 
0.3095 
0.2524 


Logistic regression 

Mean absolute difference E 

Sum 
0.3132 
0.6528 


Logistic regression (design variables) 

Mean absolute difference E 

Sum 
0.3071 
0.2648 


Mean absolute differences between theoretical and estimated penetrance matrices from 100 replications in the low and high risk scenario. 

Günther et al. BMC Genetics 2009 10:87 doi:10.1186/147121561087 