Table 4 |
||||||
|
Type I error of the uncorrected, GC and RGC-corrected tests when the markers are linked to the disease with probability 2% (nominal level is 0.05, K = 200, a = (500, 1500), b = (1500, 500), F = 0.02, f2, f1, f0 are the penetrances for AA, Aa, aa.) |
||||||
| (f0, f1, f2) |
MAF |
Method |
T0 |
T1/2 |
T1 |
 |
|
|
||||||
| (0.01, 0.02, 0.02) |
p = 0.2 |
Uncorrected |
0.470 |
0.673 |
0.657 |
0.631 |
| GC |
0.021 |
0.041 |
0.055 |
0.035 |
||
| RGC |
0.064 |
0.051 |
0.047 |
0.058 |
||
| (0.01, 0.015, 0.02) |
Uncorrected |
0.474 |
0.679 |
0.656 |
0.637 |
|
| GC |
0.018 |
0.042 |
0.056 |
0.034 |
||
| RGC |
0.056 |
0.052 |
0.051 |
0.054 |
||
| (0.01, 0.01, 0.02) |
Uncorrected |
0.473 |
0.669 |
0.653 |
0.630 |
|
| GC |
0.022 |
0.040 |
0.054 |
0.039 |
||
| RGC |
0.063 |
0.052 |
0.053 |
0.055 |
||
|
|
||||||
| (0.01, 0.02, 0.02) |
p = 0.45 |
Uncorrected |
0.592 |
0.668 |
0.615 |
0.630 |
| GC |
0.098 |
0.046 |
0.034 |
0.062 |
||
| RGC |
0.054 |
0.051 |
0.046 |
0.049 |
||
| (0.01, 0.015, 0.02) |
Uncorrected |
0.608 |
0.675 |
0.619 |
0.638 |
|
| GC |
0.105 |
0.045 |
0.033 |
0.060 |
||
| RGC |
0.053 |
0.052 |
0.053 |
0.050 |
||
| (0.01, 0.01, 0.02) |
Uncorrected |
0.598 |
0.670 |
0.620 |
0.631 |
|
| GC |
0.103 |
0.045 |
0.034 |
0.061 |
||
| RGC |
0.049 |
0.051 |
0.054 |
0.048 |
||
|
|
||||||
|
Yan et al. BMC Genetics 2009 10:78 doi:10.1186/1471-2156-10-78 |
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