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Open Access Highly Accessed Methodology article

Determining the effectiveness of High Resolution Melting analysis for SNP genotyping and mutation scanning at the TP53 locus

Sonia Garritano, Federica Gemignani, Catherine Voegele, Tú Nguyen-Dumont, Florence Le Calvez-Kelm, Deepika De Silva, Fabienne Lesueur, Stefano Landi and Sean V Tavtigian*

BMC Genetics 2009, 10:5  doi:10.1186/1471-2156-10-5

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Figure 4 has the text mixed up between parts A, B, and C

Cameron Gundry   (2009-03-16 15:07)  Idaho Technology email

Figure 4 has the text mixed up between parts A, B. 4A is the unlabeled probe data, which has more noise than typically seen. 4B is for scanning.

The figure 4 legend should read as follows:
"Figure 4. Simultaneous genotyping of common SNP rs9894946 and rare SNP rs17883532. A. In genotyping mode using an unlabeled probe for rs9894946, the 3 genotypes are distinguisable (CC in gray, CT in red, TT in blue). B. In mutation scanning mode, heterozygous samples for either the first (in red) or the second SNP (in green) have virtually indistinguishable melting curves. C. Mutation scanning of homozygous rs9894946 CC subset reveals heterozygous rs17883532 CT (In green)."

Competing interests

I work for Idaho Technology.

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