Table 4 |
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|
Step 2 using r2 LD threshold: Summary descriptive statistics of average maximum NPL LOD scores and average IC for families with 2, 3 or 4 affected sibling and ungenotyped* parents. |
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|
2 affected sibs |
3 affected sibs |
4 affected sibs |
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|
Method |
LD threshold |
Ave # SNPs |
MLS (SD) |
IC |
MLS (SD) |
IC |
MLS (SD) |
IC |
|
|
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|
Unadjusted |
3713 |
9.62 (2.75) |
0.72 |
14.01 (3.43) |
0.80 |
5.02 (1.95) |
0.85 |
|
|
RE |
0.7 |
1562 |
1.39 (0.98) |
0.73 |
2.00 (1.28) |
0.80 |
0.73 (0.70) |
0.85 |
|
RE |
0.5 |
1240 |
1.21 (0.90) |
0.73 |
1.67 (1.17) |
0.81 |
0.59 (0.63) |
0.85 |
|
RE |
0.3 |
892 |
0.45 (0.53) |
0.73 |
0.66 (0.68) |
0.81 |
0.26 (0.39) |
0.85 |
|
RE |
0.1 |
435 |
0.32 (0.44) |
0.72 |
0.40 (0.49) |
0.80 |
0.18 (0.34) |
0.85 |
|
MERLINLD |
0.7 |
562 |
1.35 (0.97) |
0.73 |
1.83 (1.22) |
0.80 |
0.62 (0.61) |
0.85 |
|
MERLINLD |
0.5 |
575 |
1.12 (0.96) |
0.73 |
1.53 (1.19) |
0.80 |
0.53 (0.59) |
0.85 |
|
MERLINLD |
0.3 |
542 |
0.55 (0.61) |
0.74 |
0.77 (0.77) |
0.80 |
0.32 (0.43) |
0.85 |
|
MERLINLD |
0.1 |
423 |
0.51 (0.58) |
0.74 |
0.69 (0.70) |
0.81 |
0.29 (0.41) |
0.85 |
|
SNPLINK |
0.7 |
2596 |
3.94 (1.85) |
0.73 |
5.10 (2.11) |
0.80 |
2.06 (1.23) |
0.85 |
|
SNPLINK |
0.5 |
2351 |
3.63 (1.81) |
0.73 |
4.88 (2.09) |
0.80 |
1.97 (1.20) |
0.85 |
|
SNPLINK |
0.3 |
2057 |
3.04 (1.73) |
0.73 |
4.10 (1.95) |
0.80 |
1.56 (1.07) |
0.85 |
|
SNPLINK |
0.1 |
1519 |
2.69 (1.64) |
0.73 |
3.57 (1.87) |
0.80 |
1.28 (0.98) |
0.85 |
|
|
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|
*With complete data where both parents are genotyped, the unadjusted average MLS for 2, 3 or 4 affected sibs are 0.58, 0.5 and 0.47 |
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|
Cho and Dupuis BMC Genetics 2009 10:44 doi:10.1186/1471-2156-10-44 |
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