Type I error and power comparison between causality methods derived from computer simulated F2 mouse crosses. For each autosome of each replicate cross of N = 1000 total crosses, a clinical trait and potential mediating trait were simulated under a variety of true causal scenarios. For each scenario, a wide range of positive and negative effect sizes were randomly selected for each chromosome of each cross. 'Neighbors' denote chromosome-specific QTL peak pairs. Causal models are, causal (C), reactive (R), independent (I), hidden variable affecting both traits (H), and no associations between genotypes and traits (Null). Unlike all other results reported here, the causal model was tested using the gene QTL peak marker and the reactive model was tested using the clinical trait QTL peak marker.
Millstein et al. BMC Genetics 2009 10:23 doi:10.1186/1471-2156-10-23