Negative log 10 p-values for the semi-parametric and non-parametric versions of the CIT applied to 10,000 replicate data sets simulated under the independence model. For each replicate of 100 observations the genetic variance for the gene and the trait were each randomly sampled from a uniform distribution ranging from 8 to 32 percent. The gene and trait were normally distributed and a biallelic locus was simulated with allele frequency of .5.
Millstein et al. BMC Genetics 2009 10:23 doi:10.1186/1471-2156-10-23