BMC Evolutionary Biology

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Open Access Highly Access Research article

Phylogenetic diversity of stress signalling pathways in fungi

Elissavet Nikolaou1, Ino Agrafioti2, Michael Stumpf2, Janet Quinn3, Ian Stansfield1 and Alistair JP Brown1*

Author Affiliations

1 Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK

2 Centre for Bioinformatics, Division of Molecular Biosciences, Wolfson Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK

3 Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, 3rd Floor, Catherine Cookson Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

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BMC Evolutionary Biology 2009, 9:44 doi:10.1186/1471-2148-9-44

Published: 21 February 2009

Additional files

Additional file 1:

Sensitivity of fungi to different stresses. Fungal stress sensitivity data: (A) sorbitol; (B) H2O2; (C) enadione sodium bisulfite; (D) Calcofluor White; (E) Congo Red.

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Additional file 2:

List of fungal orthologues. Lists of reciprocal best hits: (A) complete list of all fungal orthologues; (B) osmotic stress signalling orthologues; (C) oxidative stress signalling orthologues; (D) cell wall cell stress signalling orthologues.

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Additional file 3:

Conservation of fungal osmotic, oxidative and cell wall stress pathways. Figures illustrating the degree of conservation of signalling molecules on stress pathways in each of the fungal species examined: (A) osmotic stress signalling pathway; (B) oxidative stress signalling pathway; (C) cell wall cell stress signalling pathway.

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Additional file 4:

No correlation exists between fungal stress phenotypes and the degree of conservation of fungal stress regulators. Plot showing no significant correlation between the degree of conservation of oxidative stress regulators and the resistance of the fungal species to oxidative stress.

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Additional file 5:

Proteins used for phylogenetic analysis. Details of fungal orthologues used to construc the phylogenetic tree.

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