Alignment of DPP's deduced amino acid sequences from the BMP1-cleavage domain through the RGD/vestigial integrin-binding motifs. (A) Note the conservation of the BMP1/tolloid-related protease cleavage domain (MQXDD). The underlined MQGDDP sequences were directly encoded by the 5' PCR primer during the production of an amplicon for that species. Due to direct sequencing of the original amplicon, only a portion of the bat sequence was available. The conserved RGD domains (red) are aligned with the vestigial tripeptides (bold). (B) In addition to the loss of their original RGD domains, the platypus was found to contain an RGD domain in a portion of DSP while the common shrew had two RGD motifs within DPP and 5' to the stop codon (*).
McKnight and Fisher BMC Evolutionary Biology 2009 9:299 doi:10.1186/1471-2148-9-299