Table 1

Proteins implicated in the Notch pathway and their known functions

Component type/role

Component name and abbreviation


Receptor

Notch


Ligands

Delta/Jagged


Fucosyltransferase

O-fucosyltransferase (O-fut)


Glycosyltransferase

Fringe


Cleavage S1

Furin


Cleavage S2

ADAM 17 = TACE


Metalloproteases

ADAM 10 = Kuzbanian


Cleavage S3

Presenilin (Pres)

Nicastrin

γ-secretase complex

Anterior Pharynx defective 1 (APH1)

Presenilin Enhancer 2 (PEN2)


Transcriptional complex

CSL (CBF1, Su(H), Lag-1)

Silencing Mediator of Retinoid and Thyroid receptors

(SMRT)


Targets

Hairy Enhancer of Split (HES)


Ligand

Neuralized (Neur)

Regulation

Mindbomb (Mib)


Receptor

Deltex

Regulation

NEDD4/Suppressor of Deltex (Su(dx))

Mastermind (MAM)

Numb

Notchless (Nle)

Strawberry notch (Sno)


Gazave et al. BMC Evolutionary Biology 2009 9:249   doi:10.1186/1471-2148-9-249

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