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Open Access Research article

The genome sequence of the protostome Daphnia pulex encodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

Karen HS Wilson

BMC Evolutionary Biology 2009, 9:243  doi:10.1186/1471-2148-9-243

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Clarification on NRKs

Karen Wilson   (2009-11-19 09:36)  University of Gothenburg , The Sven Lovén Centre for Marine Sciences -Kristineberg, S-450 34 Fiskebäckskil, Sweden email

In the manuscript, NRKs refer to Drosophila melanogaster NRK orthologues lacking, like Drosophila melanogaster NRK, an "NPxY" adaptor sequence prior to the tyrosine kinase domain. NRKs have however been shown to be orthologues of the Musk family of RTKs in deuterostomes (Sossin WS, 2006: Brain Behav Evol.; 68(3):145-56).

Competing interests

No competing interests.

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Musks are the vertebrate NRK orthologue

Wayne Sossin   (2009-11-19 09:35)  McGill University email

In the manuscript it is stated that there are no deuterostome orthologues of the Nrk family. However, we had earlier pointed out that the Nrk family is orthologous to the deuterostome Musk family (Sossin, 2006 BBE 68:145-156). The Musk family, despite its close similarity to Rors and Trks was not examined in this manuscript.

Competing interests

None

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