Figure 1.

Conservation of mouse frame-preserving (left) and frame-disrupting (right) cassette exons with different inclusion level in human, dog and rat genomes for different groups of genes: (A, B, C) rapidly, moderately, and slowly evolving genes, respectively. Top plots: blue diamonds, red squares and green triangles – the fraction of mouse cassette exons conserved in the human, dog and rat genomes, respectively. Crescent pie charts below: the segment sizes are proportional to the number of exons conserved in the human, dog and rat genomes (grey), exons conserved in the rat genome and in the human or dog genome but not both (blue and red, respectively), exons conserved only in the rat genome (dark green for estimated functional conservation, brown for residual conservation, see the text for details), mouse-specific exons (green).