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Open Access Highly Accessed Research article

Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution

Dana K Howe and Dee R Denver*

Author Affiliations

Department of Zoology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon, 97331, USA

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BMC Evolutionary Biology 2008, 8:62  doi:10.1186/1471-2148-8-62

Published: 26 February 2008

Additional files

Additional File 1:

Alignment of ND5 and ψND5-1 elements from C. briggsae and Caenorhabditis sp. n. 5. This figure shows alignments of ND5 and ψND5-1 that were performed using ClustalW (gap parameters set to default: open = 10, extend = 5); residues conserved in all four sequences are in red. The sequence from isolate AF16 was used to represent C. briggsae and sequence from isolates JU727 represented Caenorhabditis sp. n. 5. The entire ψND5-1 sequences were input into the alignment program whereas input ND5 sequences included only the first 990 bp. As with C. briggsae, the ψND5-1 element in Caenorhabditis sp. n. 5 is located between the tRNAQ and tRNAF genes.

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Additional File 2:

ND5 deletion heteroplasmy data. This supplementary table provides conventional PCR band scoring data and qPCR results for ND5 deletion heteroplasmy analyses.

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Additional File 3:

πNand πSvalues for mtDNA protein-coding genes. This supplementary table reports individual nucleotide diversity estimates used to calculate πNS ratios.

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