Open Access Research article

Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals

Christina M Laukaitis1, Andreas Heger2, Tyler D Blakley3, Pavel Munclinger4, Chris P Ponting5 and Robert C Karn6*

Author Affiliations

1 Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, USA

2 MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

3 Department of Biological Sciences, Butler University, Indianapolis, USA

4 Department of Zoology, Faculty of Sciences, Charles University in Prague, Praha, Czech Republic

5 MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

6 Department of Biological Sciences, Butler University, Indianapolis, USA and Department of Genome Sciences, University of Washington, Seattle, USA

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BMC Evolutionary Biology 2008, 8:46  doi:10.1186/1471-2148-8-46

Published: 12 February 2008

Additional files

Additional file 1:

cDNA sequences of Abp genes predicted from genomic sequencing data. FASTA formatted Abp gene sequences.

Format: DOC Size: 138KB Download file

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Additional file 2:

Names, strands, and genomic locations of Abp genes. Table showing Abp genes, locations, and genomic locations. Old and new names are listed and cross-referenced.

Format: DOC Size: 387KB Download file

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Additional file 3:

Predicted and sequenced intron sequences for rodent and rabbit Abpa genes. FASTA formatted intron 2 sequences for rodent and rabbit Abpa genes used in constructing Figure 2.

Format: TXT Size: 77KB Download file

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Additional file 4:

PAML values for tests of positive selection on Abp genes. Table of PAML log likelihood ratio test statistics comparing models M7/M8 and M1/M2 for Abpa or Abpbg genes.

Format: DOC Size: 35KB Download file

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Additional file 5:

Selected sites on Abpbg superimposed on ribbon structure of cat Fel dI. Beta subunit backbone is shown in blue with side chains of selected amino acids colored red. Analysis was performed with all cow, rabbit, and mouse paralogs.

Format: JPEG Size: 68KB Download file

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Additional file 6:

Selected sites on Abpbg superimposed on ribbon structure of cat Fel dI. Beta subunit backbone is shown in blue with side chains of selected amino acids colored red. Analysis was performed with only mouse paralogs.

Format: JPEG Size: 63KB Download file

Open Data

Additional file 7:

Selected sites on Abpa superimposed on ribbon structure of cat Fel dI. Alpha subunit backbone is shown in blue with side chains of selected amino acids colored red. Analysis was performed with only rabbit paralogs.

Format: JPEG Size: 61KB Download file

Open Data

Additional file 8:

Selected sites on Abpbg superimposed on ribbon structure of cat Fel dI. Beta subunit backbone is shown in blue with side chains of selected amino acids colored red. Analysis was performed with only rabbit paralogs.

Format: JPEG Size: 54KB Download file

Open Data

Additional file 9:

Selected sites on Abpbg superimposed on ribbon structure of cat Fel dI. Beta subunit backbone is shown in blue with side chains of selected amino acids colored red. Analysis was performed with only cow paralogs.

Format: JPEG Size: 59KB Download file

Open Data

Additional file 10:

L23a pseudogene tree. Neighbor-joining tree showing phylogenetic relationships of L23a pseudogenes found in the Abp-containing region of mouse chromosome 7.

Format: JPEG Size: 43KB Download file

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Additional file 11:

Abp EST references for non-rodent taxa. References to ESTs corresponding to Abp genes in non-rodent taxa.

Format: DOC Size: 24KB Download file

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