Figure 7.

Phylogenetic trees of JmjC subfamilies. (A) A phylogenetic tree of JmjC genes in KDM4, KDM5, PKDM7, PKDM8 and KDM9 subfamilies. The tree was constructed using JmjN and JmjC domain regions as well as another region which is conserved among these five subfamilies. (B) A phylogenetic tree of KDM3 subfamily. The tree was constructed based on RING domain, JmjC domain and other conserved regions inside this subfamily. Proteins with mutated cofactor binding sites are indicated by asterisk.