Table 1 

Different measures used for asserting domain combination tendencies 

Measure 
Abbr. 
Description 
Reference 


Cooccurrence 
NCO 
Number of domains that are found at least once in the same proteins as the given domain 
[7] 
Number of neighbours 
NN 
Number of direct neighbours found for a given domain 
[26] 
Number of triplets 
NTRP 
For a given domain A, number of different combinations X – A – Y, where X and Y are domains or N or Ctermini 
[12] 
Weighted bigram frequency index 
π_{i} 
See original paper for exact definition 
[32] 
Domain versatility index 
DV I 
Strength of the relationship between the number of occurrences and the number of neighbours 
this study 


Weiner et al. BMC Evolutionary Biology 2008 8:285 doi:10.1186/147121488285 