Examplary calculation of the DVI. Exemplary calculation of the DV I. Sets of proteins belonging to two distinct genomes are indicated as strings of domains represented by boxes in the top left. The occurrence of two exemplary domains, A and B, is displayed in the table, along with two measures of domain promiscuity. N denotes the total occurrence, NN the total number of direct neighbours and NCO the total number of co-occurrences for a given domain in its respective genome. Grey shaded fields within the NN and NCO fields indicate the specific domains that yield the respective values. In essence, the DV I represents the strength of the relationship between N and NN, indicated by the graph to the right. Each line represents a domain as indicated by associated boxes. The slope for the two domains, A and B, signifies the DV I. The desired unlinking of the versatility measurement from the total occurrence is clearly illustrated; despite the overall lower occurrence of domain B, it tends to form new combinations more readily indicated by the steeper slope in the relationship between N and NN.
Weiner et al. BMC Evolutionary Biology 2008 8:285 doi:10.1186/1471-2148-8-285