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Open Access Research article

Genetic conflict outweighs heterogametic incompatibility in the mouse hybrid zone?

Miloš Macholán12*, Stuart JE Baird34, Pavel Munclinger5, Petra Dufková67, Barbora Bímová7 and Jaroslav Piálek7

Author Affiliations

1 Laboratory of Mammalian Evolutionary Genetics, Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic (ASCR), Brno, Czech Republic

2 Institute of Botany and Zoology, Masaryk University, Brno, Czech Republic

3 INRA, Centre de Biologie et de Gestion des Populations, Campus International de Baillarguet, Montferrier-sur-Lez, France

4 CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal

5 Biodiversity Research Group, Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

6 Department of Genetics, University of South Bohemia, Èeské Budìjovice, Czech Republic

7 Department of Population Biology, Institute of Vertebrate Biology, ASCR, Studenec, Czech Republic

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BMC Evolutionary Biology 2008, 8:271  doi:10.1186/1471-2148-8-271

Published: 3 October 2008

Abstract

Background

The Mus musculus musculus/M. m. domesticus contact zone in Europe is characterised by sharp frequency discontinuities for sex chromosome markers at the centre of wider clines in allozyme frequencies.

Results

We identify a triangular area (approximately 330 km2) where the musculus Y chromosome introgresses across this front for up to 22 km into domesticus territory. Introgression of the Y chromosome is accompanied by a perturbation of the census sex ratio: the sex ratio is significantly female biased in musculus localities and domesticus localities lacking Y chromosome introgression. In contrast, where the musculus Y is detected in domesticus localities, the sex ratio is close to parity, and significantly different from both classes of female biased localities. The geographic position of an abrupt cline in an X chromosome marker, and autosomal clines centred on the same position, seem unaffected by the musculus Y introgression.

Conclusion

We conclude that sex ratio distortion is playing a role in the geographic separation of speciation genes in this section of the mouse hybrid zone. We suggest that clines for genes involved in sex-ratio distortion have escaped from the centre of the mouse hybrid zone, causing a decay in the barrier to gene flow between the two house mouse taxa.