Table 1

Diversity of molecular targets for representative members of the three-finger toxin gene family.

Toxin

Target

Reference

Short-, long-chain α-neurotoxins

α1-nAChR*

[3]

Long-chain α-neurotoxins

α7 nAChR*

[3]

κ-bungarotoxin

α3 and α4 nAChRs*

[3]

Muscarinic toxins

muscarinic AChRs*

[39]

Calciseptine and FS₂ toxin

L-type calcium channels

[40,41]

Dendroaspin

α_IIbβ₃ integrins

[42]

Cardiotoxins

phospholipids and glycosphingolipids

[43,44]

Cardiotoxin A5

α_vβ₃ integrins

[45]

Fasciculins

acetylcholinesterase

[46]

Hemextin AB complex

blood coagulation factor VIIa

[47]

β-cardiotoxin

β-adrenergic receptors

[48]

*nAChR, nicotinic acetylcholine receptor

Doley et al. BMC Evolutionary Biology 2008 8:196   doi:10.1186/1471-2148-8-196