Table 3

Ciona genes related to Human GPCR associated diseases.

Human Disease Category

Human GPCRs

Candidate CionaGPCRs

Autosomal Dominant Hypocalcemia (ADH), Sporadic Hypoparathyroidism, Familial Hypoparathyroidism

CaSR

ci0100130340

Hypogonadotropic hypogonadism (HH)

GNRHR

ci0100133065

ci0100134571

ci0100152622

ci0100153146

Nephrogenic diabetes insipidus (NDI)

AVPR2

ci0100139176

Precocious puberty, male Pseudohermaphroditism

LHCGR

ci0100133821

Chondrodysplasia, multi-organ disorders, metabolic disorders

PTHR1

ci0100139945

ci0100151327

Sporadic basal cell carcinoma, Somatic mutation

SMOH

ci0100150930

Hypertension, Asthma

ADRB2

ci0100130320

ci0100137803

The list of top hits among Ciona genes in a BLASTP search against human disease related GPCRs. The list is based on an E-value cut-off of ≤1e^-20 and further verification by phylogenetic analysis. The Ciona matches were checked for their alignment with the human proteins over the length of the TM region. Swiss-Prot identifiers are reported for the human GPCRs.

Kamesh et al. BMC Evolutionary Biology 2008 8:129   doi:10.1186/1471-2148-8-129