Figure 4.

A point estimate for the distribution of deleterious mutational effects on fitness in Caenorhabditis. This point estimate was computed from comparing diversity data from C. elegans and C. remanei assuming a lognormal DDME. The fraction of effectively dominant lethal mutations estimated from this distribution is biologically plausible and indicated by the spike at s = 1. The vertical line denotes the border to effective neutrality for C. elegans at N_es = 0.5. See Methods for details.