Predicted extinction times of C. elegans based on mutations in the mitochondrial genome. (A) Analytical results only. (B) Analytical and simulation results combined. See Figure 1 legend for details. Lower genomic deleterious mutation rates are chosen to reflect estimates for the mitochondrial genome (Table 1). Thin dashed lines indicate the uncertainty of the extinction time estimates for Usdm = 0.001 using the corresponding upper and lower limits of Ne, Tgen and Rmax. This plot contains 38 644 simulations with a total of 21.4 years of computing time.
Loewe and Cutter BMC Evolutionary Biology 2008 8:125 doi:10.1186/1471-2148-8-125