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Open Access Research article

Mortality selection during the 2003 European heat wave in three-spined sticklebacks: effects of parasites and MHC genotype

K Mathias Wegner12*, Martin Kalbe2, Manfred Milinski2 and Thorsten BH Reusch23

Author Affiliations

1 Department of Integrative Biology (IBZ), Experimental Ecology, ETH Zürich, Universitätstrasse 16, CH – 8092 Zürich, Switzerland

2 Max-Planck-Institute for Evolutionary Biology, Department of Evolutionary Ecology, August-Thienemann-Str. 2, 24306 Plön, Germany

3 Institute for Evolution and Biodiversity, Evolutionary Ecology, Westfälische Wilhelms-Universität, Hüfferstrasse 1, 48149 Münster, Germany

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BMC Evolutionary Biology 2008, 8:124  doi:10.1186/1471-2148-8-124

Published: 30 April 2008

Abstract

Background

Ecological interaction strength may increase under environmental stress including temperature. How such stress enhances and interacts with parasite selection is almost unknown. We studied the importance of resistance genes of the major histocompatibility complex (MHC) class II in 14 families of three-spined sticklebacks Gasterosteus aculeatus exposed to their natural macroparasites in field enclosures in the extreme summer of 2003.

Results

After a mass die-off during the 2003-European heat wave killing 78% of 277 experimental fish, we found strong differences in survival among and within families. In families with higher average parasite load fewer individuals survived. Multivariate analysis revealed that the composition of the infecting parasite fauna was family specific. Within families, individuals with an intermediate number of MHC class IIB sequence variants survived best and had the lowest parasite load among survivors, suggesting a direct functional link between MHC diversity and fitness. The within family MHC effects were, however, small compared to between family effects, suggesting that other genetic components or non-genetic effects were also important.

Conclusion

The correlation between parasite load and mortality that we found at both individual and family level might have appeared only in the extraordinary heatwave of 2003. Due to global warming the frequency of extreme climatic events is predicted to increase, which might intensify costs of parasitism and enhance selection on immune genes.