Table 1

Mammalian heme peroxidase features and functions (adapted from Clark 2000 and O'Brien 2000).

Superfamily (EC no.)

Chromosomal Location (Human)

Tissue Expression

Biological Function


MPO (1.11.1.7)

17

Neutrophils, mono-nuclear phagocytes

Microbicidal activity

EPO (1.11.1.7)

17

Eosinophils

Microbicidal activity

LPO (1.11.1.7)

17

Milk, saliva, tears and other secretions

Bacteriostatic and bactericidal activity

TPO (1.11.1.8)

2

Thyroid cell surface and cytoplasm

Thyroid hormone biosynthesis


MPO = Myeloperoxidase; EPO = Eosinophil peroxidase; LPO = Lactoperoxidase; TPO = Thyroid peroxidase.

Loughran et al. BMC Evolutionary Biology 2008 8:101   doi:10.1186/1471-2148-8-101

Open Data