Three-dimensional genotopes. The genotope of the complete bi-allelic three-locus system with eight genotypes is the regular cube, depicted in (a). The three-locus systems that arise from data structured as in Table 1 are displayed in (b), (c), and (d). The genotope (b) lacks the triple mutant, genotope (c) lacks the triple and one double mutant, and genotope (d) contains only the wild-type and the single mutants.
Beerenwinkel et al. BMC Evolutionary Biology 2007 7:60 doi:10.1186/1471-2148-7-60