Figure 1.

Cartoon representing the three dimensional structure of Rat RabGGTase complexed with REP-1 (1LTX) [29]. The α subunit is shown in green with a yellow and red parts, representing a Leucine Rich Repeat and a C2-like domain, respectively. REP1 is shown in blue with dotted blue lines representing disordered regions. The β subunit is shown in gray. The α-subunit and REP are shown in isolation on the left and right side respectively, next to cartoons representing the three dimensional structure of the paralogous α-subunit of FTase and of RabGDI (PDB codes 1FT1 [11] and 1LV0 [72], respectively).