Identification of GnRHR orthologue in C. elegans. Protein sequence alignment of Drosophila melanogaster AKHR [GenBank: AAC61523], Ce-GnRHR [GenBank: NP_491453], human GnRHR1 [GenBank: NP_000397], human rhodopsin [GenBank: NP_000530], and human vasopressin type 1A receptor [GenBank: NP_000697]. Alignment was generated in ClustalX using default gap penalties. Colored boxes indicate functionally important residues (FIRs) in human GnRHR1 and their putative homologues in the other four sequences. Similarity analysis of these FIRs is presented in Table 2. Open boxes delimit the seven transmembrane domains of human GnRHR1.
Vadakkadath Meethal et al. BMC Evolutionary Biology 2006 6:103 doi:10.1186/1471-2148-6-103