Open Access Highly Accessed Research article

Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistance

Marina V Omelchenko12, Yuri I Wolf2, Elena K Gaidamakova1, Vera Y Matrosova1, Alexander Vasilenko1, Min Zhai1, Michael J Daly1, Eugene V Koonin2 and Kira S Makarova2*

Author Affiliations

1 Department of Pathology, F.E. Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA

2 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

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BMC Evolutionary Biology 2005, 5:57  doi:10.1186/1471-2148-5-57

Published: 20 October 2005

Additional files

Additional File 1:

(contains supplementary text and supplementary tables 1S, 2S, 3S, 4S and supplementary figures 1S, 2S, 3S)

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Additional File 2:

contains the assignments of DR and TT proteins to the COG database.

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Additional File 6:

contains compressed file for all the trees (in PHYLIP format) for 122 proteins from the reconstructed gene set of the DR-TT common ancestor that showed affinity to thermophiles (see also 1: "Phylogenetic analysis of the genes of the reconstructed DR-TT common ancestor").

Format: ZIP Size: 46KB Download file

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Additional File 3:

contains DR and TT protein comparison with COGs predicted to be associated with the thermophilic phenotype.

Format: XLS Size: 43KB Download file

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Additional File 4:

contains the results of the reconstruction of the gene repertoire of the common ancestor of TT and DR.

Format: XLS Size: 393KB Download file

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Additional File 5:

contains information on taxonomic assignments for the best hits of the TT and DR proteins.

Format: XLS Size: 982KB Download file

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Additional File 7:

contains compressed file for all the trees (in PHYLIP format) for proteins from DR-TT core that had best hits to thermophiles.

Format: ZIP Size: 55KB Download file

Open Data