Ortholog identification control. a – The symmetrical best BLAST hits approach may mis-identify orthologs in rare cases where there is an ancient gene duplication followed by differential loss of paralogs. b – The dS distributions before and after removal of human-mouse orthologous pairs with dS > 3 standard deviations from the mean (see Methods).
Jordan et al. BMC Evolutionary Biology 2004 4:22 doi:10.1186/1471-2148-4-22