Table 1

The correlations among evolutionary rate, the number of interactions, and protein abundance for all studies when abundance is measured by (A) mi-croarray expression level or (B) CAI. Np and Ni are the number of proteins and interactions for each data set. The Kendall's rank correlations between variables are given by τEI, τAI, and τEA. The Kendall's partial rank correlation between evolutionary rate and the number of interactions when abundance is controlled for is given by τEI.A. All correlations have two-tailed significances of P < 10-3 unless another P value is given in parentheses.
(A)
Study
 Np
 Ni
 τEI
 τAI
 τEA
 τEI.A
Ito [12]
 505
 1007
 0.03 (0.30)
 -0.03 (0.36)
 -0.34
 0.02 (0.51)
Uetz [13]
 607
 1183
 0.01 (0.63)
 -0.01 (0.67)
 -0.35
 0.01 (0.75)
2H studies [12,13]
 893
 2034
 0.02 (0.29)
 -0.02 (0.40)
 -0.36
 0.02 (0.48)
Gavin [10]
 1039
 15224
 -0.12
 0.09
 -0.45
 -0.09
Gavin [10] untagged
 1018
 8568
 -0.08
 0.09
 -0.44
 -0.04 (0.04)
Ho [11]
 1183
 5879
 -0.18
 0.15
 -0.41
 -0.13
Ho [11] untagged
 991
 2990
 -0.28
 0.30
 -0.40
 -0.18
MS studies [10,11]
 1698
 20708
 -0.13
 0.12
 -0.42
 -0.09
MS studies [10,11] untagged
 1543
 11424
 -0.14
 0.16
 -0.42
 -0.08
synexpression [9]
 1114
 19188
 0.09
 -0.12
 -0.40
 0.05 (0.02)
gene neighborhood [9]
 765
 9882
 -0.10
 0.15
 -0.44
 -0.04 (0.15)
synthetic lethality [9]
 524
 1463
 0.02 (0.50)
 0.01 (0.71)
 -0.43
 0.03 (0.40)
gene cooccurrence [9]
 298
 1718
 -0.15
 0.07 (0.08)
 -0.36
 -0.13 (0.002)
gene fusion [9]
 222
 535
 0.04 (0.40)
 -0.03 (0.51)
 -0.37
 0.03 (0.56)
all interactions
 2846
 54258
 -0.16
 0.13
 -0.39
 -0.12
two studies
 1112
 2792
 -0.17
 0.14
 -0.42
 -0.13
three studies
 329
 556
 0.03 (0.43)
 -0.03 (0.42)
 -0.36
 0.02 (0.65)
(B)
Study
 Np
 Ni
 τEI
 τAI
 τEA
 τEI.A
Ito [12]
 528
 1049
 0.03 (0.34)
 -0.04 (0.21)
 -0.31
 0.02 (0.61)
Uetz [13]
 630
 1213
 0.01 (0.65)
 -0.06 (0.02)
 -0.32
 -0.01 (0.78)
2H studies [12,13]
 931
 2104
 0.02 (0.27)
 -0.06 (0.003)
 -0.33
 0.00 (0.90)
Gavin [10]
 1055
 15836
 -0.12
 0.08
 -0.38
 -0.10
Gavin [10] untagged
 1033
 8648
 -0.08
 0.07
 -0.37
 -0.06 (0.01)
Ho [11]
 1209
 5941
 -0.18
 0.16
 -0.42
 -0.13
Ho [11] untagged
 1013
 3019
 -0.28
 0.33
 -0.42
 -0.16
MS studies [10,11]
 1735
 20930
 -0.13
 0.11
 -0.40
 -0.10
MS studies [10,11] untagged
 1575
 11531
 -0.14
 0.15
 -0.40
 -0.09
synexpression [9]
 1163
 20291
 0.09
 -0.09
 -0.41
 0.05 (0.06)
gene neighborhood [9]
 790
 10186
 -0.09
 0.08
 -0.49
 -0.06 (0.02)
synthetic lethality [9]
 533
 1505
 0.03 (0.36)
 -0.02 (0.60)
 -0.38
 0.02 (0.49)
gene cooccurrence [9]
 309
 1767
 -0.14
 0.07 (0.07)
 -0.44
 -0.13 (0.02)
gene fusion [9]
 233
 559
 0.04 (0.41)
 -0.01 (0.74)
 -0.40
 0.03 (0.50)
all interactions
 2960
 56058
 -0.16
 0.12
 -0.38
 -0.13
two studies
 1131
 2822
 -0.17
 0.08
 -0.41
 -0.15
three studies
 332
 562
 0.03 (0.45)
 -0.07 (0.06)
 -0.41
 0.00 (0.99)

Bloom and Adami BMC Evolutionary Biology 2003 3:21   doi:10.1186/1471-2148-3-21