Figure 4.

The correlation between evolutionary rate and the number of interactions does not depend on the size of the interactions data set as it would in the absence of bias in the counting of interactions. (A) shows the correlation and data set sizes for all sets in Table 1. (B) shows how the mean and standard deviation of the correlation should depend on the data set size in the absence of experimental bias in the counting of interactions, based on sampling simulations of the mass spectrometry (green) and yeast two-hybrid (red) method of counting interactions.