Schematic representation of the electron transfer pathway through QSOX domains. As depicted, two electrons are accepted from the substrate by the CXXC motif of the QSOX Trx1 domain, within the oxidoreductase module of QSOX. From the Trx1 domain, the electrons are transferred to the sulfhydryl oxidase module of the QSOX enzyme, first to the CXXC motif of the Erv domain, then to the FAD cofactor. Ultimately, the two electrons are transferred to molecular oxygen, the terminal electron acceptor.
Limor-Waisberg et al. BMC Evolutionary Biology 2013 13:70 doi:10.1186/1471-2148-13-70